Ultraviolet radiation-induced DNA damage is prognostic for outcome in melanoma

被引：75

作者：

Trucco, Lucas D. ^{[1
]}

Mundra, Piyushkumar A. ^{[1
]}

Hogan, Kate ^{[1
]}

Garcia-Martinez, Pablo ^{[1
]}

Viros, Amaya ^{[1
]}

Mandal, Amit K. ^{[1
]}

Macagno, Nicolas ^{[2
]}

Gaudy-Marqueste, Caroline ^{[3
]}

Allan, Donald ^{[4
,5
]}

Baenke, Franziska ^{[1
]}

Cook, Martin ^{[1
]}

McManus, Clare ^{[1
]}

Sanchez-Laorden, Berta ^{[1
]}

Dhomen, Nathalie ^{[1
]}

Marais, Richard ^{[1
]}

机构：

[1] Univ Manchester, Canc Res UK Manchester Inst, Mol Oncol Grp, Manchester, Lancs, England

[2] Aix Marseille Univ, Hop Timone, APHM, Dept Pathol, Marseille, France

[3] Aix Marseille Univ, Hop Timone, APHM, Dermatol & Skin Canc Dept, Marseille, France

[4] Univ Manchester, Med Phys Dept, Manchester Acad Hlth Sci Ctr, Salford Royal NHS Fdn Trust, Salford, Lancs, England

[5] Univ Manchester, Salford Royal NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, Salford, Lancs, England

来源：

NATURE MEDICINE | 2019年 / 25卷 / 02期

基金：

欧洲研究理事会;

关键词：

MUTATIONAL PROCESSES;

D O I：

10.1038/s41591-018-0265-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The melanoma genome is dominated by ultraviolet radiation (UVR)-induced mutations. Their relevance in disease progression is unknown. Here we classify melanomas by mutation signatures and identify ten recurrently mutated UVR signature genes that predict patient survival. We validate these findings in primary human melanomas; in mice we show that this signature is imprinted by short-wavelength UVR and that four exposures to UVR are sufficient to accelerate melanomagenesis.

引用

页码：221 / +

页数：14

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