Ultraviolet radiation-induced DNA damage is prognostic for outcome in melanoma

被引：75

作者：

Trucco, Lucas D. ^{[1
]}

Mundra, Piyushkumar A. ^{[1
]}

Hogan, Kate ^{[1
]}

Garcia-Martinez, Pablo ^{[1
]}

Viros, Amaya ^{[1
]}

Mandal, Amit K. ^{[1
]}

Macagno, Nicolas ^{[2
]}

Gaudy-Marqueste, Caroline ^{[3
]}

Allan, Donald ^{[4
,5
]}

Baenke, Franziska ^{[1
]}

Cook, Martin ^{[1
]}

McManus, Clare ^{[1
]}

Sanchez-Laorden, Berta ^{[1
]}

Dhomen, Nathalie ^{[1
]}

Marais, Richard ^{[1
]}

机构：

[1] Univ Manchester, Canc Res UK Manchester Inst, Mol Oncol Grp, Manchester, Lancs, England

[2] Aix Marseille Univ, Hop Timone, APHM, Dept Pathol, Marseille, France

[3] Aix Marseille Univ, Hop Timone, APHM, Dermatol & Skin Canc Dept, Marseille, France

[4] Univ Manchester, Med Phys Dept, Manchester Acad Hlth Sci Ctr, Salford Royal NHS Fdn Trust, Salford, Lancs, England

[5] Univ Manchester, Salford Royal NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, Salford, Lancs, England

来源：

NATURE MEDICINE | 2019年 / 25卷 / 02期

基金：

欧洲研究理事会;

关键词：

MUTATIONAL PROCESSES;

D O I：

10.1038/s41591-018-0265-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The melanoma genome is dominated by ultraviolet radiation (UVR)-induced mutations. Their relevance in disease progression is unknown. Here we classify melanomas by mutation signatures and identify ten recurrently mutated UVR signature genes that predict patient survival. We validate these findings in primary human melanomas; in mice we show that this signature is imprinted by short-wavelength UVR and that four exposures to UVR are sufficient to accelerate melanomagenesis.

引用

页码：221 / +

页数：14

共 50 条

[31] IL-18 reduces ultraviolet radiation-induced DNA damage and thereby affects photoimmunosuppression
Schwarz, Agatha
Maeda, Akira
Staender, Sonja
van Steeg, Harry
Schwarz, Thomas
JOURNAL OF IMMUNOLOGY, 2006, 176 (05): : 2896 - 2901
[32] αmelanocyte-stimulating hormone protects from ultraviolet radiation-induced apoptosis and DNA damage
Böhm, M
Wolff, I
Scholzen, TE
Robinson, SJ
Healy, E
Luger, TA
Schwarz, T
Schwarz, A
JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (07) : 5795 - 5802
[33] Quenching of reactive oxygen species and ultraviolet radiation-induced oxidative DNA damage by soybean isoflavones
Wei, HC
Zhang, XS
Wang, Y
Lebwohl, M
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1996, 106 (04) : 304 - 304
[34] In situ action spectra suggest that DNA damage is involved in ultraviolet radiation-induced immunosuppression in humans
Hurks, HMH
OutLuiting, C
Vermeer, BJ
Claas, FHJ
Mommaas, AM
PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1997, 66 (01) : 76 - 81
[35] Identification of possible reactive oxygen species involved in ultraviolet radiation-induced oxidative DNA damage
Zhang, XS
Rosenstein, BS
Wang, Y
Lebwohl, M
Wei, HC
FREE RADICAL BIOLOGY AND MEDICINE, 1997, 23 (07) : 980 - 985
[36] A DNA damage checkpoint response to unrepaired ultraviolet radiation induced lesions which is defective in melanoma
Wigan, Matthew
Payey, Sandra
Brooks, Kelly
Giles, Nichole
Burgess, Andrew
Sturm, Rick
Gabrielli, Brian
CANCER RESEARCH, 2011, 71
[37] SUNSCREENS PROMOTE REPAIR OF ULTRAVIOLET RADIATION-INDUCED DERMAL DAMAGE
KLIGMAN, LH
AKIN, FJ
KLIGMAN, AM
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1983, 81 (02) : 98 - 102
[38] Efficacy of antioxidant substances and prevention of ultraviolet radiation-induced damage
Ichihashi, M
Funasaka, Y
Uddin, NA
Chakraborty, AK
Ueda, M
SKIN: INTERFACE OF A LIVING SYSTEM: PERSPECTIVE FOR SKIN CARE SYSTEM IN THE FUTURE, 1998, 1159 : 167 - 175
[39] Radiation-Induced DNA Damage in Uveal Melanoma Is Influenced by Dose Delivery and Chromosome 3 Status
Tura, Ayseguel
Zhu, Yingda
Vardanyan, Siranush
Prasuhn, Michelle
Kakkassery, Vinodh
Lueke, Julia
Merz, Hartmut
Paulsen, Frank
Rades, Dirk
Cremers, Florian
Bartz-Schmidt, Karl -Ulrich
Grisanti, Salvatore
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2024, 65 (06)
[40] Radiation-induced DNA damage and delayed induced genomic instability
Keiji Suzuki
Mitsuaki Ojima
Seiji Kodama
Masami Watanabe
Oncogene, 2003, 22 : 6988 - 6993

← 1 2 3 4 5 →