Methylation of the Vitamin D Receptor Gene in Human Disorders

被引：5
|
作者：
Gasperini, Beatrice [1 ]
Falvino, Angela [1 ]
Piccirilli, Eleonora [2 ]
Tarantino, Umberto [2 ]
Botta, Annalisa [1 ]
Visconti, Virginia Veronica [1 ]
机构：
[1] Univ Roma Tor Vergata, Dept Biomed & Prevent, Via Montpellier 1, I-00133 Rome, Italy
[2] Univ Roma Tor Vergata, Dept Clin Sci & Translat Med, Via Montpellier 1, I-00133 Rome, Italy
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 01期
关键词：
vitamin D receptor (VDR); epigenetics; DNA methylation; VDR-related diseases; 1-ALPHA; 25-DIHYDROXYVITAMIN D-3; DNA METHYLATION; VDR; EXPRESSION; 5-AZA-2'-DEOXYCYTIDINE; SUSCEPTIBILITY; EPIGENETICS; PROMOTER; CALCIUM; CELLS;
D O I：
10.3390/ijms25010107
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The Vitamin D Receptor (VDR) mediates the actions of 1,25-Dihydroxvitamin D3 (1,25(OH)2D3), which has important roles in bone homeostasis, growth/differentiation of cells, immune functions, and reduction of inflammation. Emerging evidences suggest that epigenetic modifications of the VDR gene, particularly DNA methylation, may contribute to the onset and progression of many human disorders. This review aims to summarize the available information on the role of VDR methylation signatures in different pathological contexts, including autoimmune diseases, infectious diseases, cancer, and others. The reversible nature of DNA methylation could enable the development of therapeutic strategies, offering new avenues for the management of these worldwide diseases.
引用
收藏
页数：14
相关论文
共 50 条
  • [41] Human prostatic urethra expresses vitamin D receptor and responds to vitamin D receptor ligation
    P. Comeglio
    A. K. Chavalmane
    B. Fibbi
    S. Filippi
    M. Marchetta
    M. Marini
    A. Morelli
    G. Penna
    L. Vignozzi
    G. B. Vannelli
    L. Adorini
    M. Maggi
    Journal of Endocrinological Investigation, 2010, 33 : 730 - 738
  • [42] Human prostatic urethra expresses vitamin D receptor and responds to vitamin D receptor ligation
    Comeglio, P.
    Chavalmane, A. K.
    Fibbi, B.
    Filippi, S.
    Marchetta, M.
    Marini, M.
    Morelli, A.
    Penna, G.
    Vignozzi, L.
    Vannelli, G. B.
    Adorini, L.
    Maggi, M.
    JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 2010, 33 (10) : 730 - 738
  • [43] Vitamin D Receptor Gene as a Candidate Gene for Parkinson Disease
    Butler, Megan W.
    Burt, Amber
    Edwards, Todd L.
    Zuchner, Stephan
    Scott, William K.
    Martin, Eden R.
    Vance, Jeffery M.
    Wang, Liyong
    ANNALS OF HUMAN GENETICS, 2011, 75 : 201 - 210
  • [44] The Magic Triangle in Oral Potentially Malignant Disorders: Vitamin D, Vitamin D Receptor, and Malignancy
    Khamis, Aya
    Salzer, Lara
    Schiegnitz, Eik
    Stauber, Roland H.
    Guel, Desiree
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (20)
  • [45] The relationships of vitamin D, vitamin D receptor gene polymorphisms, and vitamin D supplementation with Parkinson’s disease
    Lingling Lv
    Xuling Tan
    Xinke Peng
    Rongrong Bai
    Qile Xiao
    Ting Zou
    Jieqiong Tan
    Hainan Zhang
    Chunyu Wang
    Translational Neurodegeneration, 9
  • [46] The relationships of vitamin D, vitamin D receptor gene polymorphisms, and vitamin D supplementation with Parkinson's disease
    Lv, Lingling
    Tan, Xuling
    Peng, Xinke
    Bai, Rongrong
    Xiao, Qile
    Zou, Ting
    Tan, Jieqiong
    Zhang, Hainan
    Wang, Chunyu
    TRANSLATIONAL NEURODEGENERATION, 2020, 9 (01)
  • [47] Structural organization of the human vitamin D receptor chromosomal gene and its promoter.
    Yamamoto, H
    Kesterson, RA
    Miyamoto, K
    Taketani, Y
    Nishiwaki, E
    Tatsumi, S
    Inoue, Y
    Morita, K
    Takeda, E
    Pike, JW
    JOURNAL OF BONE AND MINERAL RESEARCH, 1997, 12 : P251 - P251
  • [48] IDENTIFICATION OF VITAMIN D RECEPTOR RESPONSE ELEMENTS IN THE HUMAN MDR1 GENE
    Saeki, Mayumi
    Kurose, Kouichi
    Tohkin, Masahiro
    Hasegawa, Ryuichi
    DRUG METABOLISM REVIEWS, 2007, 39 : 142 - 142
  • [49] POINT MUTATIONS IN THE HUMAN VITAMIN-D RECEPTOR GENE ASSOCIATED WITH HYPOCALCEMIC RICKETS
    HUGHES, MR
    MALLOY, PJ
    KIEBACK, DG
    KESTERSON, RA
    PIKE, JW
    FELDMAN, D
    OMALLEY, BW
    SCIENCE, 1988, 242 (4886) : 1702 - 1705
  • [50] The Levels of Vitamin D, Vitamin D Receptor, Homocysteine and Complex B Vitamin in Children with Autism Spectrum Disorders
    Altun, Hatice
    Kurutas, Ergul Beige
    Sahin, Nilfer
    Gungor, Olcay
    Findikli, Ebru
    CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE, 2018, 16 (04) : 383 - 390
12345