Methylation of the Vitamin D Receptor Gene in Human Disorders

被引：5
|
作者：
Gasperini, Beatrice [1 ]
Falvino, Angela [1 ]
Piccirilli, Eleonora [2 ]
Tarantino, Umberto [2 ]
Botta, Annalisa [1 ]
Visconti, Virginia Veronica [1 ]
机构：
[1] Univ Roma Tor Vergata, Dept Biomed & Prevent, Via Montpellier 1, I-00133 Rome, Italy
[2] Univ Roma Tor Vergata, Dept Clin Sci & Translat Med, Via Montpellier 1, I-00133 Rome, Italy
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 01期
关键词：
vitamin D receptor (VDR); epigenetics; DNA methylation; VDR-related diseases; 1-ALPHA; 25-DIHYDROXYVITAMIN D-3; DNA METHYLATION; VDR; EXPRESSION; 5-AZA-2'-DEOXYCYTIDINE; SUSCEPTIBILITY; EPIGENETICS; PROMOTER; CALCIUM; CELLS;
D O I：
10.3390/ijms25010107
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The Vitamin D Receptor (VDR) mediates the actions of 1,25-Dihydroxvitamin D3 (1,25(OH)2D3), which has important roles in bone homeostasis, growth/differentiation of cells, immune functions, and reduction of inflammation. Emerging evidences suggest that epigenetic modifications of the VDR gene, particularly DNA methylation, may contribute to the onset and progression of many human disorders. This review aims to summarize the available information on the role of VDR methylation signatures in different pathological contexts, including autoimmune diseases, infectious diseases, cancer, and others. The reversible nature of DNA methylation could enable the development of therapeutic strategies, offering new avenues for the management of these worldwide diseases.
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页数：14
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