The "B" side of IL-7Rα-deficient SCID

被引：0
|
作者：
Gennery, Andrew R. [1 ]
机构：
[1] Newcastle Univ, Inst Neurosci, Newcastle Upon Tyne, England
来源：
BLOOD | 2023年 / 142卷 / 13期
关键词：
CELL; DIFFERENTIATION;
D O I：
10.1182/blood.2023021475
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Hematopoietic stem cell transplantation has been the standard of care for infants with severe combined immunodeficiency (SCID) since 1968, and although the requirement for pretransplant cytoreductive chemotherapy to achieve durable reconstitution has been hotly debated, it is now clear that most SCID genotypes benefit from preparative chemotherapy. However, the requirement for preparative chemotherapy is less clear for interleukin-7 receptor alpha chain (IL-7R alpha) deficiency. In this issue of Blood, Kaiser et al(1) present data on the role of IL-7 signaling in humans that help to clarify this issue.
引用
收藏
页码：1105 / 1106
页数：2
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