The "B" side of IL-7Rα-deficient SCID

被引：0
|
作者：
Gennery, Andrew R. [1 ]
机构：
[1] Newcastle Univ, Inst Neurosci, Newcastle Upon Tyne, England
来源：
BLOOD | 2023年 / 142卷 / 13期
关键词：
CELL; DIFFERENTIATION;
D O I：
10.1182/blood.2023021475
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Hematopoietic stem cell transplantation has been the standard of care for infants with severe combined immunodeficiency (SCID) since 1968, and although the requirement for pretransplant cytoreductive chemotherapy to achieve durable reconstitution has been hotly debated, it is now clear that most SCID genotypes benefit from preparative chemotherapy. However, the requirement for preparative chemotherapy is less clear for interleukin-7 receptor alpha chain (IL-7R alpha) deficiency. In this issue of Blood, Kaiser et al(1) present data on the role of IL-7 signaling in humans that help to clarify this issue.
引用
收藏
页码：1105 / 1106
页数：2
相关论文
共 50 条
  • [31] IL-7Rα confers susceptibility to experimental autoimmune encephalomyelitis
    Walline, C. C.
    Kanakasabai, S.
    Bright, J. J.
    GENES AND IMMUNITY, 2011, 12 (01) : 1 - 14
  • [32] IL-7R expression and IL-7 signaling confer a distinct phenotype on developing human B-lineage cells
    Nodland, Sonja E.
    Berkowska, Magdalena A.
    Bajer, Anna A.
    Shah, Nisha
    de Ridder, Dick
    van Dongen, Jacques J. M.
    LeBien, Tucker W.
    van Zelm, Menno C.
    BLOOD, 2011, 118 (08) : 2116 - 2127
  • [33] Binary control of CAR-CTL by transgenic IL-7 and IL-7R expression
    Bajgain, Pradip
    Mucharla, Roopa
    Heslop, Helen E.
    Vera, Juan F.
    CANCER RESEARCH, 2012, 72
  • [34] IL-2Rβ/IL-7Rα doubly deficient mice recapitulate the thymic and intraepithelial T cell defects of γc-/- mice.
    Porter, BO
    Malek, TR
    FASEB JOURNAL, 1999, 13 (05): : A1145 - A1145
  • [35] The Therapeutic Values of IL-7/IL-7R and the Recombinant Derivatives in Glioma: A Narrative Review
    Hesari, Marjan
    Attar, Zeinab
    Soltani-Shirazi, Shakiba
    Keshavarzian, Omid
    Taheri, Reza
    Tabrizi, Reza
    Fouladseresht, Hamed
    JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, 2023, 43 (08): : 319 - 334
  • [36] IL-7Rα expression of leukemia cells and identification of two alternatively spliced transcripts encoding different truncated IL-7Rα proteins in childhood ALL.
    Korte, A
    Badiali, L
    Köchling, J
    Schmid, H
    Geilen, W
    Eckert, C
    Kebelmann-Betzing, C
    Henze, G
    Seeger, K
    BLOOD, 1999, 94 (10) : 72A - 72A
  • [37] IL-7 and IL-7R regulate fetal macrophage establishment via survival and proliferation
    Leung, Gabriel
    Valencia, Clint
    Krum, Brian
    Beaudin, Anna E.
    JOURNAL OF IMMUNOLOGY, 2022, 208 (01):
  • [38] ANALYSIS OF SINGLE NUCLEOTIDE POLYMORPHISMS IN THE IL-7R AND IL-7 GENE IN SSc PATIENTS
    Moinzadeh, P.
    Fonseca, C.
    Abraham, D. J.
    Ong, V. H.
    Denton, C. P.
    RHEUMATOLOGY, 2012, 51 : 76 - 76
  • [39] Development of regulatory T cells requires IL-7Rα stimulation by IL-7 or TSLP
    Mazzucchelli, Renata
    Hixon, Julie A.
    Spolski, Rosanne
    Chen, Xin
    Li, Wen Qing
    Hall, Veronica L.
    Willette-Brown, Jami
    Hurwitz, Arthur A.
    Leonard, Warren J.
    Durum, Scott K.
    BLOOD, 2008, 112 (08) : 3283 - 3292
  • [40] Therapeutic targeting of IL-7Rα signaling pathways in ALL treatment
    Cramer, Sarah D.
    Aplan, Peter D.
    Durum, Scott K.
    BLOOD, 2016, 128 (04) : 473 - 478
12345