IL-7Rα and multiple sclerosis risk

被引:9
|
作者
Harley, John B.
机构
[1] Oklahoma Med Res Fdn, Arthrit & Immunol Program, Oklahoma City, OK 73104 USA
[2] US Dept Vet Affairs, Med Ctr, Oklahoma City, OK 73104 USA
关键词
D O I
10.1038/ng0907-1053
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
The discovery of genetic risk factors for multiple sclerosis has proven difficult. IL- 7R alpha, encoded by IL7R, is a pleiomorphic cytokine receptor now implicated in the pathogenesis of multiple sclerosis in independently replicated genetic association studies.
引用
收藏
页码:1053 / 1054
页数:2
相关论文
共 50 条
  • [1] IL-7Rα and multiple sclerosis risk
    John B Harley
    Nature Genetics, 2007, 39 : 1053 - 1054
  • [2] Decreased systemic IL-7 and soluble IL-7Rα in multiple sclerosis patients
    K L Kreft
    E Verbraak
    A F Wierenga-Wolf
    M van Meurs
    B A Oostra
    J D Laman
    R Q Hintzen
    Genes & Immunity, 2012, 13 : 587 - 592
  • [3] Decreased systemic IL-7 and soluble IL-7Rα in multiple sclerosis patients
    Kreft, K. L.
    Verbraak, E.
    Wierenga-Wolf, A. F.
    van Meurs, M.
    Oostra, B. A.
    Laman, J. D.
    Hintzen, R. Q.
    GENES AND IMMUNITY, 2012, 13 (07) : 587 - 592
  • [4] IL-7R alpha polymorphisms in 60 Iranian multiple sclerosis patients
    Raji, Mojgan Ahmadzadeh
    Khosravi, Alireza
    Sanati, Mohammad Hossein
    Nabavi, Seyed Massood
    Hajihoseini, Reza
    Ebrahimi, Ahmad
    Sabour, Mohammad Hossein
    IRANIAN JOURNAL OF NEUROLOGY, 2012, 11 (01) : 6 - 11
  • [5] CD8+Effector Memory T Cells and IL-7Rα Function in Multiple Sclerosis
    Kreft, Karim
    Verbraak, Evert
    Wierenga-Wolf, Annet
    van Meurs, Marjan
    Laman, Jon
    Hintzen, Rogier
    CLINICAL IMMUNOLOGY, 2010, 135 : S115 - S115
  • [6] The IL-7Rα Pathway Is Quantitatively and Functionally Altered in CD8 T Cells in Multiple Sclerosis
    Kreft, Karim L.
    Verbraak, Evert
    Wierenga-Wolf, Annet F.
    van Meurs, Marjan
    Oostra, Ben A.
    Laman, Jon D.
    Hintzen, Rogier Q.
    JOURNAL OF IMMUNOLOGY, 2012, 188 (04): : 1874 - 1883
  • [7] Significance of IL-7 and IL-7R in RA and autoimmunity
    Meyer, Anja
    Parmar, Prashant J.
    Shahrara, Shiva
    AUTOIMMUNITY REVIEWS, 2022, 21 (07)
  • [8] Targeting the IL-7R pathway in leukemia
    Durum, Scott
    Hixon, Julie
    Senkevitch, Emilee
    Cramer, Sarah
    Barata, Joao
    Walsh, Scott
    Li, Wenqing
    CYTOKINE, 2017, 100 : 181 - 181
  • [9] Targeting the IL-7R pathway in leukemia
    Durum, Scott Kenneth
    Hixon, Julie
    Senkevitch, Emilee
    Cramer, Sarah
    Barata, Joao
    Walsh, Scott
    Li, Wenqing
    CYTOKINE, 2015, 76 (01) : 76 - 76
  • [10] Retroviral transduction of IL-7Rα into IL-7Rα−/− bone marrow progenitors: correction of lymphoid deficiency and induction of neutrophilia
    Q Jiang
    W-Q Li
    F B Aiello
    K D Klarmann
    J R Keller
    S K Durum
    Gene Therapy, 2005, 12 : 1761 - 1768