Covalent Rescue of Mutant p53

被引：1
|
作者：
Lane, David P. [3 ,5 ]
Verma, Chandra S. [1 ,2 ,4 ]
机构：
[1] Karolinska Inst Biomedicum, Dept Microbiol Tumor & Cell Biol, Solnavagen 9, Solna, Sweden
[2] Bioinformat Inst A STAR, Singapore, Singapore
[3] Nanyang Technol Univ, Sch Biol Sci, Singapore, Singapore
[4] Natl Univ Singapore, Dept Biol Sci, Singapore, Singapore
[5] Karolinska Inst, MTC, S-17165 Stockholm, Sweden
来源：
CANCER DISCOVERY | 2023年 / 13卷 / 01期
关键词：
D O I：
10.1158/2159-8290.CD-22-1212
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
p53 mutant proteins are widely expressed in human cancer. In this issue, Guiley and Shokat describe the development of compounds that rescue the function of the Y220C mutant p53 protein by forming covalent complexes with the target protein.
引用
收藏
页码：14 / 16
页数：3
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