Covalent Rescue of Mutant p53

被引：1
|
作者：
Lane, David P. [3 ,5 ]
Verma, Chandra S. [1 ,2 ,4 ]
机构：
[1] Karolinska Inst Biomedicum, Dept Microbiol Tumor & Cell Biol, Solnavagen 9, Solna, Sweden
[2] Bioinformat Inst A STAR, Singapore, Singapore
[3] Nanyang Technol Univ, Sch Biol Sci, Singapore, Singapore
[4] Natl Univ Singapore, Dept Biol Sci, Singapore, Singapore
[5] Karolinska Inst, MTC, S-17165 Stockholm, Sweden
来源：
CANCER DISCOVERY | 2023年 / 13卷 / 01期
关键词：
D O I：
10.1158/2159-8290.CD-22-1212
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
p53 mutant proteins are widely expressed in human cancer. In this issue, Guiley and Shokat describe the development of compounds that rescue the function of the Y220C mutant p53 protein by forming covalent complexes with the target protein.
引用
收藏
页码：14 / 16
页数：3
相关论文
共 50 条
  • [11] A novel mutant p53 binding partner BAG5 stabilizes mutant p53 and promotes mutant p53 GOFs in tumorigenesis
    Yue, Xuetian
    Zhao, Yuhan
    Huang, Grace
    Li, Jun
    Zhu, Junlan
    Feng, Zhaohui
    Hu, Wenwei
    CELL DISCOVERY, 2016, 2
  • [12] Attack of the mutant p53
    Sarah Seton-Rogers
    Nature Reviews Cancer, 2009, 9 : 384 - 385
  • [13] Pontin, a novel interactor of mutant p53 that promotes mutant p53 gain of function
    Zhao, Yuhan
    Yue, Xuetian
    Hu, Wenwei
    MOLECULAR & CELLULAR ONCOLOGY, 2016, 3 (02)
  • [14] p53's Extended Reach: The Mutant p53 Secretome
    Pavlakis, Evangelos
    Stiewe, Thorsten
    BIOMOLECULES, 2020, 10 (02)
  • [15] Rescue of the apoptotic-inducing function of mutant p53 by small molecule RITA
    Zhao, Carolyn Y.
    Grinkevich, Vera V.
    Nikulenkov, Fedor
    Bao, Wenjie
    Selivanova, Galina
    CELL CYCLE, 2010, 9 (09) : 1847 - 1855
  • [16] Halogen-Enriched Fragment Libraries as Leads for Drug Rescue of Mutant p53
    Wilcken, Rainer
    Liu, Xiangrui
    Zimmermann, Markus O.
    Rutherford, Trevor J.
    Fersht, Alan R.
    Joerger, Andreas C.
    Boeckler, Frank M.
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2012, 134 (15) : 6810 - 6818
  • [17] PRIMA-1 Reactivates Mutant p53 by Covalent Binding to the Core Domain
    Lambert, Jeremy M. R.
    Gorzov, Petr
    Veprintsev, Dimitry B.
    Soderqvist, Maja
    Segerback, Dan
    Bergman, Jan
    Fersht, Alan R.
    Hainaut, Pierre
    Wiman, Klas G.
    Bykov, Vladimir J. N.
    CANCER CELL, 2009, 15 (05) : 376 - 388
  • [18] Mutant p53 Gain of Function and Chemoresistance: The Role of Mutant p53 in Response to Clinical Chemotherapy
    He, Chao
    Li, Lun
    Guan, Xuan
    Xiong, Li
    Miao, Xiongying
    CHEMOTHERAPY, 2017, 62 (01) : 43 - 53
  • [19] Understanding the prowess of mutant p53
    McCarthy, Nicola
    NATURE REVIEWS CANCER, 2014, 14 (06) : 385 - 385
  • [20] Mutant p53 on the Path to Metastasis
    Tang, Qiaosi
    Su, Zhenyi
    Gu, Wei
    Rustgi, Anil K.
    TRENDS IN CANCER, 2020, 6 (01): : 62 - 73
12345