Virologic and Immunologic Characterization of Coronavirus Disease 2019 Recrudescence After Nirmatrelvir/Ritonavir Treatment

被引：42

作者：

Carlin, Aaron F. ^{[1
]}

Clark, Alex E. ^{[1
]}

Chaillon, Antoine ^{[1
]}

Garretson, Aaron F. ^{[1
]}

Bray, William ^{[2
]}

Porrachia, Magali ^{[1
]}

Santos, AsherLev T. ^{[3
]}

Rana, Tariq M. ^{[4
]}

Smith, Davey M. ^{[1
,5
]}

机构：

[1] Univ Calif San Diego, Sch Med, Dept Med, 9500 Gilman Dr, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Sch Med, Dept Pediat, La Jolla, CA 92093 USA

[3] Calif State Univ San Marcos, Coll Educ Hlth & Human Serv, Dept Publ Hlth, San Marcos, CA USA

[4] Univ Calif San Diego, UCSD Ctr AIDS Res, Inst Genom Med, Dept Pediat Program Immunol,Div Genet, La Jolla, CA 92093 USA

[5] Vet Affairs San Diego Healthcare Syst, San Diego, CA USA

来源：

CLINICAL INFECTIOUS DISEASES | 2023年 / 76卷 / 03期

关键词：

COVID-19; treatment rebound; recrudescence; nirmatrelvir; Omicron;

D O I：

10.1093/cid/ciac496

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We isolated a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) BA.2 variant from a person with coronavirus disease 2019 recrudescence after nirmatrelvir/ritonavir treatment. Antiviral sensitivity and neutralizing antibody testing were performed with both parental SARS-CoV-2 and multiple variants of concern. We found that neither nirmatrelvir resistance nor absence of neutralizing immunity was a likely cause of the recrudescence.

引用

页码：E530 / E532

页数：3

共 50 条

[41] Successful Treatment of Prolonged, Severe Coronavirus Disease 2019 (COVID-19) Lower Respiratory Tract Disease in a B-cell Acute Lymphoblastic Leukemia (ALL) Patient With an Extended Course of Remdesivir and Nirmatrelvir/Ritonavir
Ford, Emily S.
Simmons, William
Karmarkar, Ellora N.
Yoke, Leah H.
Braimah, Ayodale B.
Orozco, Johnnie J.
Ghiuzeli, Cristina M.
Barnhill, Serena
Sack, Coralynn L.
Benditt, Joshua O.
Roychoudhury, Pavitra
Greninger, Alexander L.
Shapiro, Adrienne E.
Hammond, Jennifer L.
Rusnak, James M.
Dolsten, Mikael
Boeckh, Michael
Liu, Catherine
Cheng, Guang-Shing
Corey, Lawrence
CLINICAL INFECTIOUS DISEASES, 2023, 76 (05) : 926 - 929
[42] Drug-induced Liver Injury With Ritonavir-Boosted Nirmatrelvir: Evidence From Coronavirus Disease 2019 Emergency Use Authorization Adverse Event Reporting System
Li, Guo-Fu
Yu, Guo
GASTROENTEROLOGY, 2023, 165 (01) : 305 - 306
[43] Retinal Artery and Vein Occlusion Risks after Coronavirus Disease 2019 or Coronavirus Disease 2019 Vaccination
Park, Hyo Song
Lee, Nang Kyeong
Lee, Christopher Seungkyu
Byeon, Suk Ho
Kim, Sung Soo
Lee, Seung Won
Kim, Yong Joon
OPHTHALMOLOGY, 2024, 131 (03) : 322 - 332
[44] Thyroid storm after coronavirus disease 2019 mRNA vaccination in a patient with a history of Graves' disease after coronavirus disease 2019 infection
Saito, Masahiro
Iijima, Toshie
Kurai, Hidetaka
Aso, Yosimasa
BMJ CASE REPORTS, 2024, 17 (06)
[45] Seroconversion After Coronavirus Disease 2019 Vaccination
Sookaromdee, Pathum
Wiwanitkit, Viroj
LIVER TRANSPLANTATION, 2022, 28 (03) : 514 - 514
[46] Pharmacokinetics of Lopinavir and Ritonavir in Patients Hospitalized With Coronavirus Disease 2019 (COVID-19)
Schoergenhofer, Christian
Jilma, Bernd
Stimpfl, Thomas
Karolyi, Mario
Zoufaly, Alexander
ANNALS OF INTERNAL MEDICINE, 2020, 173 (08) : 670 - +
[47] Symptoms, Viral Loads, and Rebound Among Coronavirus Disease 2019 (COVID-19) Outpatients Treated With Nirmatrelvir/Ritonavir Compared With Propensity Score-Matched Untreated Individuals
Smith-Jeffcoat, Sarah E.
Biddle, Jessica E.
Talbot, H. Keipp
Morrissey, Kerry Grace
Stockwell, Melissa S.
Maldonado, Yvonne
McLean, Huong Q.
Ellingson, Katherine D.
Bowman, Natalie M.
Asturias, Edwin
Mellis, Alexandra M.
Johnson, Sheroi
Kirking, Hannah L.
Rolfes, Melissa A. R.
Olivo, Vanessa
Merrill, Lori
Battan-Wraith, Steph
Sano, Ellen
McLaren, Son H.
Vargas, Celibell Y.
Goodman, Sara
Sarnquist, Clea C.
Govindaranjan, Prasanthi
Petrie, Joshua G.
Belongia, Edward A.
Ledezma, Karla
Pryor, Kathleen
Lutrick, Karen
Bullock, Ayla
Yang, Amy
Haehnel, Quenla
Rao, Suchitra
Zhu, Yuwei
Schmitz, Jonathan
Hart, Kimberly
Grijalva, Carlos G.
Salvatore, Phillip P.
CLINICAL INFECTIOUS DISEASES, 2023, : 1175 - 1184
[48] Coronavirus Disease 2019 Treatment: It is Time for Stewardship!
Nasa, Prashant
INDIAN JOURNAL OF CRITICAL CARE MEDICINE, 2020, 24 (10) : 895 - 896
[49] Treatment of Coronavirus Disease 2019: Shooting in the Dark
Tamargo, Juan
EUROPEAN CARDIOLOGY REVIEW, 2020, 15
[50] Modalities and Mechanisms of Treatment for Coronavirus Disease 2019
Zuo, Zhihong
Wu, Ting
Pan, Liangyu
Zuo, Chenzhe
Hu, Yingchuo
Luo, Xuan
Jiang, Liping
Xia, Zanxian
Xiao, Xiaojuan
Liu, Jing
Ye, Mao
Deng, Meichun
FRONTIERS IN PHARMACOLOGY, 2021, 11

← 1 2 3 4 5 →