Virologic and Immunologic Characterization of Coronavirus Disease 2019 Recrudescence After Nirmatrelvir/Ritonavir Treatment

被引：42

作者：

Carlin, Aaron F. ^{[1
]}

Clark, Alex E. ^{[1
]}

Chaillon, Antoine ^{[1
]}

Garretson, Aaron F. ^{[1
]}

Bray, William ^{[2
]}

Porrachia, Magali ^{[1
]}

Santos, AsherLev T. ^{[3
]}

Rana, Tariq M. ^{[4
]}

Smith, Davey M. ^{[1
,5
]}

机构：

[1] Univ Calif San Diego, Sch Med, Dept Med, 9500 Gilman Dr, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Sch Med, Dept Pediat, La Jolla, CA 92093 USA

[3] Calif State Univ San Marcos, Coll Educ Hlth & Human Serv, Dept Publ Hlth, San Marcos, CA USA

[4] Univ Calif San Diego, UCSD Ctr AIDS Res, Inst Genom Med, Dept Pediat Program Immunol,Div Genet, La Jolla, CA 92093 USA

[5] Vet Affairs San Diego Healthcare Syst, San Diego, CA USA

来源：

CLINICAL INFECTIOUS DISEASES | 2023年 / 76卷 / 03期

关键词：

COVID-19; treatment rebound; recrudescence; nirmatrelvir; Omicron;

D O I：

10.1093/cid/ciac496

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We isolated a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) BA.2 variant from a person with coronavirus disease 2019 recrudescence after nirmatrelvir/ritonavir treatment. Antiviral sensitivity and neutralizing antibody testing were performed with both parental SARS-CoV-2 and multiple variants of concern. We found that neither nirmatrelvir resistance nor absence of neutralizing immunity was a likely cause of the recrudescence.

引用

页码：E530 / E532

页数：3

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