Mutagenesis reveals how Akkermansia muciniphila degrades mucin and colonizes the gut

被引：1
|
作者：
Valdivia, Raphael H. [1 ]
Davey, Lauren [2 ]
机构：
[1] Duke Univ, Sch Med, Durham, NC 27708 USA
[2] Univ Victoria, Victoria, BC, Canada
来源：
NATURE MICROBIOLOGY | 2023年 / 8卷 / 08期
关键词：
MICROBIOTA;
D O I：
10.1038/s41564-023-01408-9
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Mutational analysis of Akkermansia muciniphila identified genes important for growth in mucin and gut colonization. Mucin-degrading capabilities are essential for the bacterium to compete with other members of the microbiota, and mucin metabolism by A.muciniphila resulted in reduced transcription of genes involved with cholesterol biosynthesis in the host gut.
引用
收藏
页码：1384 / 1385
页数：2
相关论文
共 50 条
  • [41] Akkermansia muciniphila ameliorates inflammatory bowel disease by modulating gut tight junctions in mice
    Wade, H.
    Su, Q.
    PROCEEDINGS OF THE NUTRITION SOCIETY, 2021, 80 (OCE3)
  • [42] Effect of inulin, galacto-oligosaccharides, and polyphenols on the gut microbiota, with a focus on Akkermansia muciniphila
    Tian, Ruocen
    Yu, Leilei
    Tian, Fengwei
    Zhao, Jianxin
    Chen, Wei
    Zhai, Qixiao
    FOOD & FUNCTION, 2024, 15 (09) : 4763 - 4772
  • [43] Akkermansia muciniphila and Bifidobacterium bifidum Prevent NAFLD by Regulating FXR Expression and Gut Microbiota
    Nian, Fulin
    Wu, Longyun
    Xia, Qiaoyun
    Tian, Peiying
    Ding, Chunmei
    Lu, Xiaolan
    JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY, 2023, 11 (04) : 763 - 776
  • [44] Reduced Akkermansia muciniphila and Faecalibacterium prausnitzii levels in the gut microbiota of children with allergic asthma
    Demirci, M.
    Tokman, H. B.
    Uysal, H. K.
    Demiryas, S.
    Karakullukcu, A.
    Saribas, S.
    Cokugras, H.
    Kocazeybek, B. S.
    ALLERGOLOGIA ET IMMUNOPATHOLOGIA, 2019, 47 (04) : 365 - 371
  • [45] The lipooligosaccharide of the gut symbiont Akkermansia muciniphila exhibits a remarkable structure and TLR signaling capacity
    Garcia-Vello, Pilar
    Tytgat, Hanne L. P.
    Elzinga, Janneke
    Van Hul, Matthias
    Plovier, Hubert
    Tiemblo-Martin, Marta
    Cani, Patrice D.
    Nicolardi, Simone
    Fragai, Marco
    De Castro, Cristina
    Di Lorenzo, Flaviana
    Silipo, Alba
    Molinaro, Antonio
    de Vos, Willem M.
    NATURE COMMUNICATIONS, 2024, 15 (01)
  • [46] Identification of a Novel Cobamide Remodeling Enzyme in the Beneficial Human Gut Bacterium Akkermansia muciniphila
    Mok, Kenny C.
    Sokolovskaya, Olga M.
    Nicolas, Alexa M.
    Hallberg, Zachary F.
    Deutschbauer, Adam
    Carlson, Hans K.
    Taga, Michiko E.
    MBIO, 2020, 11 (06): : 1 - 18
  • [47] An insight into multifunctional tool box: Akkermansia muciniphila provides dynamic benefits to the human gut
    Tiwari, Kartikeya
    REVIEWS AND RESEARCH IN MEDICAL MICROBIOLOGY, 2022, 33 (02): : 82 - 91
  • [48] Function of Akkermansia muciniphila in Obesity: Interactions With Lipid Metabolism, Immune Response and Gut Systems
    Xu, Yu
    Wang, Ning
    Tan, Hor-Yue
    Li, Sha
    Zhang, Cheng
    Feng, Yibin
    FRONTIERS IN MICROBIOLOGY, 2020, 11
  • [49] Akkermansia muciniphila induces gut microbiota remodelling and controls islet autoimmunity in NOD mice
    Hanninen, Arno
    Toivonen, Raine
    Poysti, Sakari
    Belzer, Clara
    Plovier, Hubert
    Ouwerkerk, Janneke P.
    Emani, Rohini
    Cani, Patrice D.
    De Vos, Willem M.
    GUT, 2018, 67 (08) : 1445 - 1453
  • [50] Modulation of mucosal immune response, tolerance, and proliferation in mice colonized by the mucin-degrader Akkermansia muciniphila
    Derrien, Muriel
    Van Baarlen, Peter
    Hooiveld, Guido
    Norin, Elisabeth
    Muller, Michael
    de Vos, Willem M.
    FRONTIERS IN MICROBIOLOGY, 2011, 2
12345