Mutagenesis reveals how Akkermansia muciniphila degrades mucin and colonizes the gut

被引：1

作者：

Valdivia, Raphael H. ^{[1
]}

Davey, Lauren ^{[2
]}

机构：

[1] Duke Univ, Sch Med, Durham, NC 27708 USA

[2] Univ Victoria, Victoria, BC, Canada

来源：

NATURE MICROBIOLOGY | 2023年 / 8卷 / 08期

关键词：

MICROBIOTA;

D O I：

10.1038/s41564-023-01408-9

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Mutational analysis of Akkermansia muciniphila identified genes important for growth in mucin and gut colonization. Mucin-degrading capabilities are essential for the bacterium to compete with other members of the microbiota, and mucin metabolism by A.muciniphila resulted in reduced transcription of genes involved with cholesterol biosynthesis in the host gut.

引用

页码：1384 / 1385

页数：2

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