Acetaminophen-induced liver injury at therapeutic doses in a young adult: a case report

被引：0

作者：

Tajirika, Satoko ^{[1
,2
]}

Yamamoto, Mayumi ^{[1
,3
]}

Matsushita, Tomomichi ^{[4
]}

Yamada, Tetsuya ^{[5
]}

Shimizu, Masahito ^{[2
]}

机构：

[1] Gifu Univ, Hlth Adm Ctr, 1-1 Yanagido, Gifu, Gifu 5011193, Japan

[2] Gifu Univ, Grad Sch Med, Dept Gastroenterol Internal Med, Gifu 5011194, Japan

[3] Gifu Univ, United Grad Sch Drug Discovery & Med Informat Sci, Gifu 5011194, Japan

[4] Japanese Red Cross Gifu Hosp, Dept Gastroenterol, Gifu 5028511, Japan

[5] Cent Japan Int Med Ctr, Dept Pathol, Gifu 5058510, Japan

来源：

CLINICAL JOURNAL OF GASTROENTEROLOGY | 2024年 / 17卷 / 01期

关键词：

Acetaminophen; Drug-induced liver injury; Drug-induced lymphocyte stimulation test; Liver biopsy; Young adult; SCALE;

D O I：

10.1007/s12328-023-01883-x

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Acetaminophen causes volume-dependent hepatotoxicity; however, hepatotoxicity may also occur with acetaminophen administered at normal doses. We encountered a case of allergic liver damage in a 17-year-old girl receiving acetaminophen at a regular dose. The patient was diagnosed using the Roussel Uclaf Causality Assessment Method (RUCAM) and the diagnostic scale of the Digestive Disease Week Japan 2004 workshop. She tested positive for acetaminophen on a drug-induced lymphocyte stimulation test, and liver biopsy results confirmed the diagnosis of acetaminophen-induced liver injury. Despite administering acetaminophen at normal doses, hepatotoxicity may occur, which warrants further exploration.

引用

页码：130 / 136

页数：7

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