Acetaminophen-induced liver injury at therapeutic doses in a young adult: a case report

被引：0

作者：

Tajirika, Satoko ^{[1
,2
]}

Yamamoto, Mayumi ^{[1
,3
]}

Matsushita, Tomomichi ^{[4
]}

Yamada, Tetsuya ^{[5
]}

Shimizu, Masahito ^{[2
]}

机构：

[1] Gifu Univ, Hlth Adm Ctr, 1-1 Yanagido, Gifu, Gifu 5011193, Japan

[2] Gifu Univ, Grad Sch Med, Dept Gastroenterol Internal Med, Gifu 5011194, Japan

[3] Gifu Univ, United Grad Sch Drug Discovery & Med Informat Sci, Gifu 5011194, Japan

[4] Japanese Red Cross Gifu Hosp, Dept Gastroenterol, Gifu 5028511, Japan

[5] Cent Japan Int Med Ctr, Dept Pathol, Gifu 5058510, Japan

来源：

CLINICAL JOURNAL OF GASTROENTEROLOGY | 2024年 / 17卷 / 01期

关键词：

Acetaminophen; Drug-induced liver injury; Drug-induced lymphocyte stimulation test; Liver biopsy; Young adult; SCALE;

D O I：

10.1007/s12328-023-01883-x

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Acetaminophen causes volume-dependent hepatotoxicity; however, hepatotoxicity may also occur with acetaminophen administered at normal doses. We encountered a case of allergic liver damage in a 17-year-old girl receiving acetaminophen at a regular dose. The patient was diagnosed using the Roussel Uclaf Causality Assessment Method (RUCAM) and the diagnostic scale of the Digestive Disease Week Japan 2004 workshop. She tested positive for acetaminophen on a drug-induced lymphocyte stimulation test, and liver biopsy results confirmed the diagnosis of acetaminophen-induced liver injury. Despite administering acetaminophen at normal doses, hepatotoxicity may occur, which warrants further exploration.

引用

页码：130 / 136

页数：7

共 50 条

[21] ACETAMINOPHEN-INDUCED RENAL TUBULAR INJURY WITH CONCURRENT HEPATOTOXICITY - A CASE REPORT
George, Bistees
Rizvi, Asim
Kompella, Divya
John, Jaison
Sogbein, Olusola
Lal, Yasir
AMERICAN JOURNAL OF KIDNEY DISEASES, 2021, 77 (04) : 595 - 595
[22] Complement Activation in Acetaminophen-Induced Liver Injury in Mice
Singhal, Rohit
Ganey, Patricia E.
Roth, Robert A.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2012, 341 (02): : 377 - 385
[23] Role of Parkin in Acetaminophen-induced Mitophagy and Liver Injury
Williams, Jessica A.
Ni, Hong-Min
Ding, Wen-Xing
HEPATOLOGY, 2013, 58 : 377A - 377A
[24] Osthole prevents acetaminophen-induced liver injury in mice
Yun Cai
Wu Sun
Xin-xin Zhang
Yan-die Lin
Hao Chen
Hao Li
Acta Pharmacologica Sinica, 2018, 39 : 74 - 84
[25] Latex Proteins from Plumeria pudica with Therapeutic Potential on Acetaminophen-Induced Liver Injury
Souza, Bruna da Silva
Silva Sales, Ana Clara
Soares da Silva, Francisca Dayane
de Souza, Thalis Ferreira
Teixeira de Freitas, Cleverson Diniz
Pereira Vasconcelos, Daniel Fernando
de Oliveira, Jefferson Soares
MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2020, 20 (19) : 2011 - 2018
[26] Therapeutic Potential of Plants and Plant Derived Phytochemicals against Acetaminophen-Induced Liver Injury
Subramanya, Sandeep B.
Venkataraman, Balaji
Meeran, Mohamed Fizur Nagoor
Goyal, Sameer N.
Patil, Chandragouda R.
Ojha, Shreesh
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018, 19 (12)
[27] Translational biomarkers of acetaminophen-induced acute liver injury
Beger, Richard D.
Bhattacharyya, Sudeepa
Yang, Xi
Gill, Pritmohinder S.
Schnackenberg, Laura K.
Sun, Jinchun
James, Laura P.
ARCHIVES OF TOXICOLOGY, 2015, 89 (09) : 1497 - 1522
[28] Loss of Autophagy Enhances Acetaminophen-Induced Liver Injury
Igusa, Yuki
Yamashina, Shunhei
Izumi, Kousuke
Fukada, Hiroo
Mikirai, Abuduxueke
Inami, Yoshihiro
Kon, Kazuyoshi
Ikejima, Kenichi
Watanabe, Sumio
GASTROENTEROLOGY, 2010, 138 (05) : S808 - S808
[29] Effect of growth factors on acetaminophen-induced liver injury
Nam, T.
Hwang, H.
Kim, I.
FEBS JOURNAL, 2007, 274 : 138 - 138
[30] Targeting Autophagy for Acetaminophen-Induced Liver Injury: An Update
Hinz, Kaitlyn
Niu, Mengwei
Ni, Hong-Min
Ding, Wen-Xing
LIVERS, 2024, 4 (03): : 377 - 387

← 1 2 3 4 5 →