Mechanisms and therapeutic prospects of mesenchymal stem cells-derived exosomes for tendinopathy

被引：4
|
作者：
Zhang, Yuxiang [1 ,2 ,3 ]
Ju, Wei [4 ]
Zhang, Hong [2 ,3 ,4 ,5 ,6 ]
Mengyun, Liu [4 ,5 ,7 ,8 ]
Shen, Weiliang [4 ,5 ,6 ,7 ,8 ]
Chen, Xiao [4 ,5 ,6 ,7 ,8 ]
机构：
[1] Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept Plast Surg, Hangzhou, Peoples R China
[2] Zhejiang Univ, Dr Li Dak Sum & Yip Yio Chin Ctr Stem Cell & Regen, Sch Med, Sir Run Run Shaw Hosp, Hangzhou, Peoples R China
[3] Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept Orthoped Surg, Hangzhou, Peoples R China
[4] Zhejiang Univ, Sch Med, Key Lab Tissue Engn & Regenerat Med Zhejiang Prov, Hangzhou, Peoples R China
[5] Zhejiang Univ, Dept Sports Med, Sch Med, Hangzhou, Peoples R China
[6] China Orthoped Regenerat Med Grp CORMed, Hangzhou, Peoples R China
[7] Zhejiang Univ, Affiliated Hosp 2, Dr Li Dak Sum Yip Yio Chin Ctr Stem Cells & Regene, Sch Med, Hangzhou, Peoples R China
[8] Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Orthoped Surg, Hangzhou, Peoples R China
来源：
STEM CELL RESEARCH & THERAPY | 2023年 / 14卷 / 01期
关键词：
Tendinopathy; Exosomes; Mesenchymal stem cells; Therapeutics; ROTATOR CUFF TENDINOPATHY; BONE-MARROW; TENDON; BIOGENESIS; SECRETION; BETA;
D O I：
10.1186/s13287-023-03431-3
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Tendinopathy is a debilitating and crippling syndrome resulting from the degeneration of tendon tissue, leading to loss of mechanical properties and function, and eventual tendon rupture. Unfortunately, there is currently no treatment for tendinopathy that can prevent or delay its progression. Exosomes are small extracellular vesicles that transport bioactive substances produced by cells, such as proteins, lipids, mRNAs, non-coding RNAs, and DNA. They can generate by mesenchymal stem cells (MSCs) throughout the body and play a role in intercellular communication and regulation of homeostasis. Recent research suggests that MSCs-derived exosomes (MSCs-exos) may serve as useful therapeutic candidates for promoting tendon healing. This review focuses on the function and mechanisms of MSCs-exos in tendinopathy treatment and discusses their potential application for treating this condition.
引用
收藏
页数：10
相关论文
共 50 条
  • [41] Melatonin improves therapeutic potential of mesenchymal stem cells-derived exosomes against renal ischemia-reperfusion injury in rats
    Alzahrani, Faisal A.
    AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH, 2019, 11 (05): : 2887 - 2907
  • [42] The potential use of mesenchymal stem cells-derived exosomes as microRNAs delivery systems in different diseases
    Oveili, Elham
    Vafaei, Somayeh
    Bazavar, Haniyeh
    Eslami, Yeganeh
    Mamaghanizadeh, Ehsan
    Yasamineh, Saman
    Gholizadeh, Omid
    CELL COMMUNICATION AND SIGNALING, 2023, 21 (01)
  • [43] Mesenchymal stem cells-derived and siRNAs-encapsulated exosomes inhibit osteonecrosis of the femoral head
    Zhang, Chi
    Su, Yan
    Ding, Hao
    Yin, Jimin
    Zhu, Zhenhong
    Song, Wenqi
    JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2020, 24 (17) : 9605 - 9612
  • [44] Bone marrow mesenchymal stem cells-derived exosomes for penetrating and targeted chemotherapy of pancreatic cancer
    Yu Zhou
    Wenxi Zhou
    Xinli Chen
    Qingbing Wang
    Chao Li
    Qinjun Chen
    Yu Zhang
    Yifei Lu
    Xiaoyi Ding
    Chen Jiang
    ActaPharmaceuticaSinicaB, 2020, 10 (08) : 1563 - 1575
  • [45] The effect of mesenchymal stem cells-derived exosomes on the prostate, bladder, and renal cancer cell lines
    Rezaeian, AhmadReza
    Khatami, Fatemeh
    Keshel, Saeed Heidari
    Akbari, Mohammad Reza
    Mirzaei, Akram
    Gholami, Keykavos
    Farsani, Reza Mohammadi
    Aghamir, Seyed Mohammad Kazem
    SCIENTIFIC REPORTS, 2022, 12 (01):
  • [46] Mesenchymal stem cells-derived exosomes loaded with siRNA for spinal cord injury treatment in rat
    Huang, W.
    Zhang, S.
    Liu, T.
    Wu, B. L.
    Duan, R. M.
    Yuan, Y. S.
    Qu, M. J.
    Zhang, X. Z.
    Zhang, M.
    Shang, D. P.
    Yu, X. B.
    BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2018, 123 : 7 - 8
  • [47] The Effects of Mesenchymal Stem Cells-Derived Exosomes on Metabolic Reprogramming in Scar Formation and Wound Healing
    Gong, Xiangan
    Zhao, Qian
    Zhang, Huimin
    Liu, Rui
    Wu, Jie
    Zhang, Nanxin
    Zou, Yuanxian
    Zhao, Wen
    Huo, Ran
    Cui, Rongtao
    INTERNATIONAL JOURNAL OF NANOMEDICINE, 2024, 19 : 9871 - 9887
  • [48] The effect of mesenchymal stem cells-derived exosomes on the prostate, bladder, and renal cancer cell lines
    AhmadReza Rezaeian
    Fatemeh Khatami
    Saeed Heidari Keshel
    Mohammad Reza Akbari
    Akram Mirzaei
    Keykavos Gholami
    Reza Mohammadi Farsani
    Seyed Mohammad Kazem Aghamir
    Scientific Reports, 12 (1)
  • [49] Urine-derived mesenchymal stem cells-derived exosomes enhances survival and proliferation of aging retinal ganglion cells
    Dan, Qi-Qin
    Chen, Li
    Shi, Lan-Lan
    Zhou, Xiu
    Wang, Ting-Hua
    Liu, Hua
    BMC MOLECULAR AND CELL BIOLOGY, 2023, 24 (01)
  • [50] Urine-derived mesenchymal stem cells-derived exosomes enhances survival and proliferation of aging retinal ganglion cells
    Qi-Qin Dan
    Li Chen
    Lan-Lan shi
    Xiu Zhou
    Ting-Hua Wang
    Hua Liu
    BMC Molecular and Cell Biology, 24
12345