Mechanisms and therapeutic prospects of mesenchymal stem cells-derived exosomes for tendinopathy

被引：4
|
作者：
Zhang, Yuxiang [1 ,2 ,3 ]
Ju, Wei [4 ]
Zhang, Hong [2 ,3 ,4 ,5 ,6 ]
Mengyun, Liu [4 ,5 ,7 ,8 ]
Shen, Weiliang [4 ,5 ,6 ,7 ,8 ]
Chen, Xiao [4 ,5 ,6 ,7 ,8 ]
机构：
[1] Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept Plast Surg, Hangzhou, Peoples R China
[2] Zhejiang Univ, Dr Li Dak Sum & Yip Yio Chin Ctr Stem Cell & Regen, Sch Med, Sir Run Run Shaw Hosp, Hangzhou, Peoples R China
[3] Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept Orthoped Surg, Hangzhou, Peoples R China
[4] Zhejiang Univ, Sch Med, Key Lab Tissue Engn & Regenerat Med Zhejiang Prov, Hangzhou, Peoples R China
[5] Zhejiang Univ, Dept Sports Med, Sch Med, Hangzhou, Peoples R China
[6] China Orthoped Regenerat Med Grp CORMed, Hangzhou, Peoples R China
[7] Zhejiang Univ, Affiliated Hosp 2, Dr Li Dak Sum Yip Yio Chin Ctr Stem Cells & Regene, Sch Med, Hangzhou, Peoples R China
[8] Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Orthoped Surg, Hangzhou, Peoples R China
来源：
STEM CELL RESEARCH & THERAPY | 2023年 / 14卷 / 01期
关键词：
Tendinopathy; Exosomes; Mesenchymal stem cells; Therapeutics; ROTATOR CUFF TENDINOPATHY; BONE-MARROW; TENDON; BIOGENESIS; SECRETION; BETA;
D O I：
10.1186/s13287-023-03431-3
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Tendinopathy is a debilitating and crippling syndrome resulting from the degeneration of tendon tissue, leading to loss of mechanical properties and function, and eventual tendon rupture. Unfortunately, there is currently no treatment for tendinopathy that can prevent or delay its progression. Exosomes are small extracellular vesicles that transport bioactive substances produced by cells, such as proteins, lipids, mRNAs, non-coding RNAs, and DNA. They can generate by mesenchymal stem cells (MSCs) throughout the body and play a role in intercellular communication and regulation of homeostasis. Recent research suggests that MSCs-derived exosomes (MSCs-exos) may serve as useful therapeutic candidates for promoting tendon healing. This review focuses on the function and mechanisms of MSCs-exos in tendinopathy treatment and discusses their potential application for treating this condition.
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页数：10
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