ERAP1 and the return of the UPR in ankylosing spondylitis

被引：1
|
作者：
Haroon, Nigil [1 ,2 ]
Inman, Robert D. [1 ,2 ]
机构：
[1] Univ Hlth Network, Schroder Arthrit Inst, Krembil Res Inst, Div Rheumatol, Toronto, ON, Canada
[2] Univ Toronto, Dept Med, Div Rheumatol, Toronto, ON, Canada
来源：
NATURE REVIEWS RHEUMATOLOGY | 2023年 / 19卷 / 03期
关键词：
UNFOLDED PROTEIN RESPONSE; HLA-B27;
D O I：
10.1038/s41584-023-00910-y
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The mechanisms underlying the genetic association between HLA-B27 and ankylosing spondylitis, including the contribution of endoplasmic reticulum aminopeptidase 1 (ERAP1), continue to elude the field. New findings support the involvement of the unfolded protein response and highlight the therapeutic potential and limitations of targeting ERAP1 in this disease.
引用
收藏
页码：134 / 135
页数：2
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