ERAP1 and the return of the UPR in ankylosing spondylitis

被引：1

作者：

Haroon, Nigil ^{[1
,2
]}

Inman, Robert D. ^{[1
,2
]}

机构：

[1] Univ Hlth Network, Schroder Arthrit Inst, Krembil Res Inst, Div Rheumatol, Toronto, ON, Canada

[2] Univ Toronto, Dept Med, Div Rheumatol, Toronto, ON, Canada

来源：

NATURE REVIEWS RHEUMATOLOGY | 2023年 / 19卷 / 03期

关键词：

UNFOLDED PROTEIN RESPONSE; HLA-B27;

D O I：

10.1038/s41584-023-00910-y

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The mechanisms underlying the genetic association between HLA-B27 and ankylosing spondylitis, including the contribution of endoplasmic reticulum aminopeptidase 1 (ERAP1), continue to elude the field. New findings support the involvement of the unfolded protein response and highlight the therapeutic potential and limitations of targeting ERAP1 in this disease.

引用

页码：134 / 135

页数：2

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