Effect of PEGylated Graphene Oxide Nanoparticles on the Metabolism of Jurkat Cells

被引：0

作者：

Timganova, V. P. ^{[1
]}

Vlasova, V. V. ^{[1
]}

Bochkova, M. S. ^{[1
,2
]}

Shardina, K. Yu. ^{[1
]}

Uzhviyuk, S. V. ^{[1
]}

Khramtsov, P. V. ^{[1
,2
]}

Rayev, M. B. ^{[1
,2
]}

Zamorina, S. A. ^{[1
,2
]}

机构：

[1] Russian Acad Sci, Inst Ecol & Genet Microorganisms, Ural Branch, Perm Fed Res Ctr, Perm, Russia

[2] Perm State Natl Res Univ, Perm, Russia

来源：

DOKLADY BIOCHEMISTRY AND BIOPHYSICS | 2023年 / 512卷 / 01期

基金：

俄罗斯科学基金会;

关键词：

PEGylated graphene oxide nanoparticles; Jurkat cell line; metabolism; mitochondrial respiration; aerobic glycolysis;

D O I：

10.1134/S1607672923700473

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of graphene oxide (GO) nanoparticles of 100-200 nm in size coated with linear (LP-GO) and branched (BP-GO) polyethylene glycol at concentrations of 5 and 25 mu g/mL on the metabolism of Jurkat tumor cells was studied. It was found that LP-GO nanoparticles at a concentration of 25 mu g/mL can enhance basal glycolysis of Jurkat T-lymphocyte tumor cell line cells, while LP-GO and BP-GO at the same concentration can reduce the indicators of compensatory glycolysis. Despite this, GO nanoparticles coated with linear and branched PEG at a concentration of 5 mu g/mL do not have pronounced effects on oxidative phosphorylation and glycolysis of Jurkat cells and could therefore be safe for activated T cells.

引用

页码：288 / 291

页数：4

共 50 条

[31] Delivery of Oridonin and Methotrexate via PEGylated Graphene Oxide
Chai, Dongdong
Hao, Bingjie
Hu, Rong
Zhang, Fang
Yan, Jia
Sun, Yu
Huang, Xiaoyu
Zhang, Qingxiao
Jiang, Hong
ACS APPLIED MATERIALS & INTERFACES, 2019, 11 (26) : 22915 - 22924
[32] Nanoplasmonic Sensor Chip Fabricated Based on Au Nanoparticles: Effect of Graphene Oxide and Reduced Graphene Oxide
Zohreh Ayareh
Mehrdad Moradi
Plasmonics, 2022, 17 : 1437 - 1444
[33] Nanoplasmonic Sensor Chip Fabricated Based on Au Nanoparticles: Effect of Graphene Oxide and Reduced Graphene Oxide
Ayareh, Zohreh
Moradi, Mehrdad
PLASMONICS, 2022, 17 (04) : 1437 - 1444
[34] Impact of iron oxide nanoparticles on xenobiotic metabolism in HepaRG cells
Linn Voss
Kiymet Yilmaz
Lea Burkard
Janja Vidmar
Valerie Stock
Ute Hoffmann
Oliver Pötz
Helen Sophie Hammer
Matthias Peiser
Albert Braeuning
Katrin Löschner
Linda Böhmert
Holger Sieg
Archives of Toxicology, 2020, 94 : 4023 - 4035
[35] Impact of iron oxide nanoparticles on xenobiotic metabolism in HepaRG cells
Voss, Linn
Yilmaz, Kiymet
Burkard, Lea
Vidmar, Janja
Stock, Valerie
Hoffmann, Ute
Poetz, Oliver
Hammer, Helen Sophie
Peiser, Matthias
Braeuning, Albert
Loschner, Katrin
Boehmert, Linda
Sieg, Holger
ARCHIVES OF TOXICOLOGY, 2020, 94 (12) : 4023 - 4035
[36] Synthesis, physico-chemical characterization, and antioxidant effect of PEGylated cerium oxide nanoparticles
Xue, Yingfei
Balmuri, Sricharani Rao
Patel, Akhil
Sant, Vinayak
Sant, Shilpa
DRUG DELIVERY AND TRANSLATIONAL RESEARCH, 2018, 8 (02) : 357 - 367
[37] Effect of Silver Nanoparticles on the Optoelectronic Properties of Graphene Oxide Films
Alikhaidarova, E.
Seliverstova, E.
Ibrayev, N.
BULLETIN OF THE UNIVERSITY OF KARAGANDA-PHYSICS, 2023, 1 (109): : 6 - 12
[38] Particle size effect on graphene nanoribbons with iron oxide nanoparticles
Rodriguez, B. A. G.
Perez, M.
Alvarado, J.
Cerecedo-Nunez, H. H.
Valladares, L. De Los Santos
Aguiar, J. Albino
APPLIED SURFACE SCIENCE, 2024, 675
[39] Synthesis, physico-chemical characterization, and antioxidant effect of PEGylated cerium oxide nanoparticles
Yingfei Xue
Sricharani Rao Balmuri
Akhil Patel
Vinayak Sant
Shilpa Sant
Drug Delivery and Translational Research, 2018, 8 : 357 - 367
[40] Benefits of oxidation and size reduction of graphene/graphene oxide nanoparticles in biosensing application: Classification of graphene/graphene oxide nanoparticles
Milosavljevic, Vedran
Mitrevska, Katerina
Adam, Vojtech
SENSORS AND ACTUATORS B-CHEMICAL, 2022, 353

← 1 2 3 4 5 →