Effect of PEGylated Graphene Oxide Nanoparticles on the Metabolism of Jurkat Cells

被引：0

作者：

Timganova, V. P. ^{[1
]}

Vlasova, V. V. ^{[1
]}

Bochkova, M. S. ^{[1
,2
]}

Shardina, K. Yu. ^{[1
]}

Uzhviyuk, S. V. ^{[1
]}

Khramtsov, P. V. ^{[1
,2
]}

Rayev, M. B. ^{[1
,2
]}

Zamorina, S. A. ^{[1
,2
]}

机构：

[1] Russian Acad Sci, Inst Ecol & Genet Microorganisms, Ural Branch, Perm Fed Res Ctr, Perm, Russia

[2] Perm State Natl Res Univ, Perm, Russia

来源：

DOKLADY BIOCHEMISTRY AND BIOPHYSICS | 2023年 / 512卷 / 01期

基金：

俄罗斯科学基金会;

关键词：

PEGylated graphene oxide nanoparticles; Jurkat cell line; metabolism; mitochondrial respiration; aerobic glycolysis;

D O I：

10.1134/S1607672923700473

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of graphene oxide (GO) nanoparticles of 100-200 nm in size coated with linear (LP-GO) and branched (BP-GO) polyethylene glycol at concentrations of 5 and 25 mu g/mL on the metabolism of Jurkat tumor cells was studied. It was found that LP-GO nanoparticles at a concentration of 25 mu g/mL can enhance basal glycolysis of Jurkat T-lymphocyte tumor cell line cells, while LP-GO and BP-GO at the same concentration can reduce the indicators of compensatory glycolysis. Despite this, GO nanoparticles coated with linear and branched PEG at a concentration of 5 mu g/mL do not have pronounced effects on oxidative phosphorylation and glycolysis of Jurkat cells and could therefore be safe for activated T cells.

引用

页码：288 / 291

页数：4

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