Effect of PEGylated Graphene Oxide Nanoparticles on the Metabolism of Jurkat Cells

被引：0
|
作者：
Timganova, V. P. [1 ]
Vlasova, V. V. [1 ]
Bochkova, M. S. [1 ,2 ]
Shardina, K. Yu. [1 ]
Uzhviyuk, S. V. [1 ]
Khramtsov, P. V. [1 ,2 ]
Rayev, M. B. [1 ,2 ]
Zamorina, S. A. [1 ,2 ]
机构：
[1] Russian Acad Sci, Inst Ecol & Genet Microorganisms, Ural Branch, Perm Fed Res Ctr, Perm, Russia
[2] Perm State Natl Res Univ, Perm, Russia
来源：
DOKLADY BIOCHEMISTRY AND BIOPHYSICS | 2023年 / 512卷 / 01期
基金：
俄罗斯科学基金会;
关键词：
PEGylated graphene oxide nanoparticles; Jurkat cell line; metabolism; mitochondrial respiration; aerobic glycolysis;
D O I：
10.1134/S1607672923700473
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The effect of graphene oxide (GO) nanoparticles of 100-200 nm in size coated with linear (LP-GO) and branched (BP-GO) polyethylene glycol at concentrations of 5 and 25 mu g/mL on the metabolism of Jurkat tumor cells was studied. It was found that LP-GO nanoparticles at a concentration of 25 mu g/mL can enhance basal glycolysis of Jurkat T-lymphocyte tumor cell line cells, while LP-GO and BP-GO at the same concentration can reduce the indicators of compensatory glycolysis. Despite this, GO nanoparticles coated with linear and branched PEG at a concentration of 5 mu g/mL do not have pronounced effects on oxidative phosphorylation and glycolysis of Jurkat cells and could therefore be safe for activated T cells.
引用
收藏
页码：288 / 291
页数：4
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