Synthesis and biological evaluation of tetrazole ring incorporated oxazole-pyrimidine derivatives as anticancer agents

被引：2
|
作者：
Asiri, Yahya I. [1 ]
Syed, Tasqeeruddin [2 ]
Maringanti, Thirumala Chary [3 ]
Eppakayala, Laxminarayana [4 ]
Puli, Venkat Swamy [5 ]
机构：
[1] King Khalid Univ, Coll Pharm, Dept Pharmaceut Chem, Abha, Saudi Arabia
[2] King Khalid Univ, Coll Pharm, Dept Pharmacol, Abha, Saudi Arabia
[3] Jawaharlal Nehru Technol Univ Hyderabad, Hyderabad, India
[4] Sreenidhi Inst Sci & Technol Autonomous, Ghatkesar, India
[5] KoneruLakshmaiah Univ, Dept Chem, Guntur, India
来源：
SYNTHETIC COMMUNICATIONS | 2024年 / 54卷 / 10期
关键词：
Cephalosporin; infigratinib; pyrimidine; 1,2,3,4-tetrazole and anticancer activity; KINASE; POTENT; ANALOGS; DESIGN;
D O I：
10.1080/00397911.2024.2331922
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new library of tetrazole rings with oxazole-pyrimidine derivatives (9a-j) has been developed and synthesized. All of the compounds were characterized using spectral data. These were then tested for in vitro anticancer activity against four human cancer cell lines: prostate cancer (PC3 & DU-145), lung cancer (A549), and breast cancer (MCF-7) using an MTT assay. Etoposide was chosen as the positive control. Most of the compounds demonstrated moderate to good activity. These compounds (9a, 9b, 9d, 9g, and 9h) demonstrated the most powerful action. Particularly, one chemical 9h had exceptional antitumor efficacy.
引用
收藏
页码：802 / 814
页数：13
相关论文
共 50 条
  • [41] Synthesis of New Tetrazole Derivatives and Their Biological Evaluation
    Soliman, H. A.
    Kalmouch, A.
    Awad, H. M.
    Wahed, N. A. M. Abdel
    RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2018, 88 (08) : 1726 - 1733
  • [42] Design, synthesis, anticancer evaluation, molecular docking, and in silico ADME analysis of novel chalcones incorporated indole-pyrimidine derivatives as promising anticancer agents
    Boddiboyena, Ramesh
    Reddy, G. Nagendra
    Seelam, Nareshvarma
    Sarma, Monima
    Gudisela, Mura reddy
    CHEMICAL DATA COLLECTIONS, 2022, 39
  • [43] Design, Synthesis, and Anticancer Evaluation of Tetrazole-Fused Benzoxazole Derivatives as Tubulin Binding Agents
    Ravikumar, P.
    Raolji, G. S. B.
    Sastry, K. Venkata
    Kalidasu, S.
    Balaaraju, T.
    RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2018, 88 (10) : 2183 - 2189
  • [44] Synthesis, biological evaluation and molecular docking of pyrimidine and quinazoline derivatives of 1,5-benzodiazepine as potential anticancer agents
    Misra, Apoorva
    Kishore, Dharma
    Verma, Ved Prakash
    Dubey, Sunil
    Chander, Subhash
    Gupta, Neha
    Bhagyawant, Sameer
    Dwivedi, Jaya
    Alothman, Zeid A.
    Wabaidur, Saikh Mohammad
    Sharma, Swapnil
    JOURNAL OF KING SAUD UNIVERSITY SCIENCE, 2020, 32 (02) : 1486 - 1495
  • [45] DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF 3-PHENYLISOXAZOLO[5,4-D]PYRIMIDINE DERIVATIVES AS ANTICANCER AGENTS
    Gaikwad, Nikhil
    Madhavi, Y., V
    CONFERENCE ON DRUG DESIGN AND DISCOVERY TECHNOLOGIES, 2020, 355 : 87 - 90
  • [46] Design, synthesis, molecular modelling, and biological evaluation of novel substituted pyrimidine derivatives as potential anticancer agents for hepatocellular carcinoma
    Ahmed, Naglaa Mohamed
    Youns, Mahmoud
    Soltan, Moustafa Khames
    Said, Ahmed Mohammed
    JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2019, 34 (01) : 1110 - 1120
  • [47] Synthesis and biological evaluation of novel series of thieno[2,3-d]pyrimidine derivatives as anticancer and antimicrobial agents
    Habib, Nargues S.
    Soliman, Raafat
    El-Tombary, Alaa A.
    El-Hawash, Soad A.
    Shaaban, Omaima G.
    MEDICINAL CHEMISTRY RESEARCH, 2013, 22 (07) : 3289 - 3308
  • [48] Synthesis and biological evaluation of 1,3,4-oxadiazole bearing pyrimidine-pyrazine derivatives as anticancer agents
    Rachala, Muralidhar Reddy
    Maringanti, Thirumala Chary
    Syed, Tasqeeruddin
    Eppakayala, Laxminarayana
    SYNTHETIC COMMUNICATIONS, 2023, 53 (15) : 1262 - 1268
  • [49] Synthesis and biological evaluation of novel series of thieno[2,3-d]pyrimidine derivatives as anticancer and antimicrobial agents
    Nargues S. Habib
    Raafat Soliman
    Alaa A. El-Tombary
    Soad A. El-Hawash
    Omaima G. Shaaban
    Medicinal Chemistry Research, 2013, 22 : 3289 - 3308
  • [50] Design, Synthesis, and Anticancer Evaluation of Tetrazole-Fused Benzoxazole Derivatives as Tubulin Binding Agents
    P. Ravikumar
    G. S. B. Raolji
    K. Venkata Sastry
    S. Kalidasu
    T. Balaaraju
    Russian Journal of General Chemistry, 2018, 88 : 2183 - 2189
12345