Synthesis and biological evaluation of tetrazole ring incorporated oxazole-pyrimidine derivatives as anticancer agents

被引：2

作者：

Asiri, Yahya I. ^{[1
]}

Syed, Tasqeeruddin ^{[2
]}

Maringanti, Thirumala Chary ^{[3
]}

Eppakayala, Laxminarayana ^{[4
]}

Puli, Venkat Swamy ^{[5
]}

机构：

[1] King Khalid Univ, Coll Pharm, Dept Pharmaceut Chem, Abha, Saudi Arabia

[2] King Khalid Univ, Coll Pharm, Dept Pharmacol, Abha, Saudi Arabia

[3] Jawaharlal Nehru Technol Univ Hyderabad, Hyderabad, India

[4] Sreenidhi Inst Sci & Technol Autonomous, Ghatkesar, India

[5] KoneruLakshmaiah Univ, Dept Chem, Guntur, India

来源：

SYNTHETIC COMMUNICATIONS | 2024年 / 54卷 / 10期

关键词：

Cephalosporin; infigratinib; pyrimidine; 1,2,3,4-tetrazole and anticancer activity; KINASE; POTENT; ANALOGS; DESIGN;

D O I：

10.1080/00397911.2024.2331922

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new library of tetrazole rings with oxazole-pyrimidine derivatives (9a-j) has been developed and synthesized. All of the compounds were characterized using spectral data. These were then tested for in vitro anticancer activity against four human cancer cell lines: prostate cancer (PC3 & DU-145), lung cancer (A549), and breast cancer (MCF-7) using an MTT assay. Etoposide was chosen as the positive control. Most of the compounds demonstrated moderate to good activity. These compounds (9a, 9b, 9d, 9g, and 9h) demonstrated the most powerful action. Particularly, one chemical 9h had exceptional antitumor efficacy.

引用

页码：802 / 814

页数：13

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