The Diagnostic and Prognostic Potentials of TSPANs in Cancer: A Comprehensive Review

被引：0
|
作者：
Zhao, Kun [1 ,2 ]
Tian, Yijun [2 ]
Yang, Li [2 ,3 ,4 ]
Wang, Liping [5 ]
机构：
[1] Zhengzhou Univ, Dept Orthoped, Affiliated Hosp 1, Zhengzhou 450052, Henan, Peoples R China
[2] Zhengzhou Univ, Biol Cell Therapy Ctr, Affiliated Hosp 1, Zhengzhou 450052, Henan, Peoples R China
[3] Zhengzhou Univ, Sch Life Sci, Zhengzhou 450052, Henan, Peoples R China
[4] State Key Lab Esophageal Canc Prevent & Treatment, Zhengzhou 450040, Henan, Peoples R China
[5] Zhengzhou Univ, Dept Psychiat, Affiliated Hosp 1, Zhengzhou 450052, Henan, Peoples R China
来源：
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS | 2024年 / 38卷 / 01期
基金：
中国国家自然科学基金;
关键词：
tetraspanin; tumor marker; exosome; metastasis; TETRASPANIN-ENRICHED MICRODOMAINS; METASTASIS SUPPRESSOR GENE; TUMOR-CELL MOTILITY; BREAST-CANCER; COLORECTAL-CANCER; BETA-CATENIN; INTEGRIN ALPHA-3-BETA-1; MOLECULAR PATHWAYS; CD81; PROMOTES; CD151;
D O I：
10.23812/j.biol.regul.homeost.agents.20243801.7
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Tetraspanins are four transmembrane proteins that serve as a platform for interacting with a wide range of different molecules. It plays a crucial role in oncogenesis as well as in the metastasis in various cancer types. Numerous studies have investigated the use of various members of the tetraspanin family as prognostic markers and predictors of metastatic potential according to specific cancer types. This manuscript provides an overview of these advances, and their limitations, and suggests insights into future research areas for their clinical applications. Furthermore, the potential value of tetraspanin as a tumor-associated antigenic target will also be discussed in this review.
引用
收藏
页码：93 / 110
页数：18
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