Exploring the Antioxidant Potential of Talisia esculenta Using In Vitro and In Vivo Approaches

被引:2
|
作者
Cordeiro, Maria Lucia da Silva [1 ,2 ]
Aquino-Martins, Veronica Giuliani de Queiroz [1 ,2 ]
da Silva, Ariana Pereira [1 ,2 ]
Naliato, Georggia Fatima Silva [2 ,3 ]
Silveira, Elielson Rodrigo [4 ]
Theodoro, Raquel Cordeiro [2 ,3 ]
da Santos, Deborah Yara Alves Cursino [4 ]
Rocha, Hugo Alexandre Oliveira [2 ,5 ]
Scortecci, Katia Castanho [1 ,2 ]
机构
[1] Univ Fed Rio Grande Norte UFRN, Dept Biol Celular & Genet, Lab Transformacao Plantas & Anal Microscopia LTPAM, BR-59078970 Natal, RN, Brazil
[2] Univ Fed Rio Grande Norte UFRN, Ctr Biociencias, Programa Posgrad Bioquim & Biol Mol, BR-59072900 Natal, RN, Brazil
[3] Univ Fed Rio Grande Norte UFRN, Inst Med Trop, BR-59077080 Natal, RN, Brazil
[4] Univ Sao Paulo, Dept Bot, Lab Fitoquim, BR-05508090 Sao Paulo, SP, Brazil
[5] Univ Fed Rio Grande Norte UFRN, Dept Bioquim, Lab Biotecnol Polimeros Nat BIOPOL, BR-59078970 Natal, RN, Brazil
关键词
medicinal plant; phenolic compounds; Sapindaceae; Tenebrio molitor; oxidative damage; CuSO4; stress; OXIDATIVE STRESS; COPPER; IRON; CHELATION; APOPTOSIS; TOXICITY; DAMAGE; MODEL; ASSAY;
D O I
10.3390/nu15173855
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Medicinal plants, such as Talisia esculenta, are rich in antioxidant biomolecules, which are used in the treatment and prevention of many diseases. The antioxidant potential of T. esculenta extracts obtained from leaves and fruit peels was investigated using biochemical and 3T3 cell line assays as well as in vivo assays using an organism model Tenebrio molitor. Four extracts were tested: hydroethanolic extracts from leaves (HF) and from fruit peels (HC), and infusion extracts from leaves (IF) and from fruit peels (IC). The biochemical assays demonstrated an antioxidant capacity verified by TAC, reducing power, DPPH, and copper chelating assays. None of the extracts exhibited cytotoxicity against 3T3 cells, instead offering a protection against CuSO4-induced oxidative stress. The antioxidant activity observed in the extracts, including their role as free radical scavengers, copper chelators, and stress protectors, was further confirmed by T. molitor assays. The CLAE-DAD analysis detected phenolic compounds, including gallic acid, rutin, and quercitrin, as the main constituents of the samples. This study highlights that leaf and fruit peels extracts of T. esculenta could be effective protectors against ROS and copper-induced stress in cellular and invertebrate models, and they should be considered as coadjutants in the treatment and prevention of diseases related to oxidative stress and for the development of natural nutraceutical products.
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页数:20
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