Exploring the Antioxidant Potential of Talisia esculenta Using In Vitro and In Vivo Approaches

被引:2
|
作者
Cordeiro, Maria Lucia da Silva [1 ,2 ]
Aquino-Martins, Veronica Giuliani de Queiroz [1 ,2 ]
da Silva, Ariana Pereira [1 ,2 ]
Naliato, Georggia Fatima Silva [2 ,3 ]
Silveira, Elielson Rodrigo [4 ]
Theodoro, Raquel Cordeiro [2 ,3 ]
da Santos, Deborah Yara Alves Cursino [4 ]
Rocha, Hugo Alexandre Oliveira [2 ,5 ]
Scortecci, Katia Castanho [1 ,2 ]
机构
[1] Univ Fed Rio Grande Norte UFRN, Dept Biol Celular & Genet, Lab Transformacao Plantas & Anal Microscopia LTPAM, BR-59078970 Natal, RN, Brazil
[2] Univ Fed Rio Grande Norte UFRN, Ctr Biociencias, Programa Posgrad Bioquim & Biol Mol, BR-59072900 Natal, RN, Brazil
[3] Univ Fed Rio Grande Norte UFRN, Inst Med Trop, BR-59077080 Natal, RN, Brazil
[4] Univ Sao Paulo, Dept Bot, Lab Fitoquim, BR-05508090 Sao Paulo, SP, Brazil
[5] Univ Fed Rio Grande Norte UFRN, Dept Bioquim, Lab Biotecnol Polimeros Nat BIOPOL, BR-59078970 Natal, RN, Brazil
关键词
medicinal plant; phenolic compounds; Sapindaceae; Tenebrio molitor; oxidative damage; CuSO4; stress; OXIDATIVE STRESS; COPPER; IRON; CHELATION; APOPTOSIS; TOXICITY; DAMAGE; MODEL; ASSAY;
D O I
10.3390/nu15173855
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Medicinal plants, such as Talisia esculenta, are rich in antioxidant biomolecules, which are used in the treatment and prevention of many diseases. The antioxidant potential of T. esculenta extracts obtained from leaves and fruit peels was investigated using biochemical and 3T3 cell line assays as well as in vivo assays using an organism model Tenebrio molitor. Four extracts were tested: hydroethanolic extracts from leaves (HF) and from fruit peels (HC), and infusion extracts from leaves (IF) and from fruit peels (IC). The biochemical assays demonstrated an antioxidant capacity verified by TAC, reducing power, DPPH, and copper chelating assays. None of the extracts exhibited cytotoxicity against 3T3 cells, instead offering a protection against CuSO4-induced oxidative stress. The antioxidant activity observed in the extracts, including their role as free radical scavengers, copper chelators, and stress protectors, was further confirmed by T. molitor assays. The CLAE-DAD analysis detected phenolic compounds, including gallic acid, rutin, and quercitrin, as the main constituents of the samples. This study highlights that leaf and fruit peels extracts of T. esculenta could be effective protectors against ROS and copper-induced stress in cellular and invertebrate models, and they should be considered as coadjutants in the treatment and prevention of diseases related to oxidative stress and for the development of natural nutraceutical products.
引用
收藏
页数:20
相关论文
共 50 条
  • [21] Structural characterization, in vitro and in vivo antioxidant activities of a heteropolysaccharide from the fruiting bodies of Morchella esculenta
    Cai, Zheng-Nan
    Li, Wan
    Mehmood, Shomaila
    Pan, Wen-Juan
    Wang, Ya
    Meng, Fan-Ju
    Wang, Xiao-Fang
    Lu, Yong-Ming
    Chen, Yan
    CARBOHYDRATE POLYMERS, 2018, 195 : 29 - 38
  • [22] Coccoloba alnifolia Leaf Extract as a Potential Antioxidant Molecule Using In Vitro and In Vivo Assays
    de Melo, Luciana Fentanes Moura
    Gomes, Dayanne Lopes
    da Silva, Lucas Felipe
    Silva, Larissa Marina Pereira
    Machado, Marina Lopes
    Cadavid, Cesar Orlando Munoz
    Zucolotto, Silvana Maria
    de Paula Oliveira, Riva
    dos Santos, Deborah Yara Alves Cursino
    Rocha, Hugo Alexandre Oliveira
    Scortecci, Katia Castanho
    OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2020, 2020
  • [23] Extraction of bioactive compounds from peel and seeds of pitomba (Talisia esculenta) using eutectic solvents
    Souza, Pamela da Silva
    Cardoso, Flavia Aparecida Reitz
    Lima, Mirela Vanin dos Santos
    Heck, Stenio Cristaldo
    Marques, Leila Larisa Medeiros
    INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY, 2024, 59 (12): : 9060 - 9071
  • [24] Structural insights regarding an insecticidal Talisia esculenta protein and its biotechnological potential for Diatraea saccharalis larval control
    Freire, Maria das Gracas M.
    Franco, Octavio L.
    Kubo, Carlos Eduardo G.
    Migliolo, Ludovico
    Vargas, Rodrigo H.
    Ramalho de Oliveira, Caio Fernando
    Parra, Jose Roberto P.
    Macedo, Maria Ligia R.
    COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY, 2012, 161 (01): : 86 - 92
  • [25] Exploring the Cytotoxic Potential of Triterpenoids-enriched Fraction of Bacopa monnieri by Implementing In vitro, In vivo, and In silico Approaches
    Mallick, Md. Nasar
    Khan, Washim
    Parveen, Rabea
    Ahmad, Sayeed
    Sadaf
    Najm, Mohammad Zeeshan
    Ahmad, Istaq
    Husain, Syed Akhtar
    PHARMACOGNOSY MAGAZINE, 2017, 13 (51) : S595 - S606
  • [26] IN VITRO AND IN VIVO EVALUATION OF ANTIMICROBIAL AND ANTIOXIDANT POTENTIAL OF STEVIA EXTRACT
    Moselhy, Said S.
    Ghoneim, Magdy A.
    Khan, Jehan A.
    AFRICAN JOURNAL OF TRADITIONAL COMPLEMENTARY AND ALTERNATIVE MEDICINES, 2016, 13 (06) : 18 - 21
  • [27] Antioxidant potential of an extract of Calendula officinalis flowers in vitro and in vivo
    Preethi, K. C.
    Kuttan, Girija
    Kuttan, Ramadasan
    PHARMACEUTICAL BIOLOGY, 2006, 44 (09) : 691 - 697
  • [28] Exploring the anti-diabetic potential of the Vigna sesquipedalis using in vitro, in vivo and computational models
    Ahmad, Hammad
    Khan, Ashraf Ullah
    Alam, Waqas
    Darwish, Hany W.
    Pirzada, Abdul Saboor
    Khan, Haroon
    JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, 2025, 39 (01)
  • [29] Study on Gluco-Regulatory Potential of Glimepiride Sulfonamide Using In silico, In Vitro and In Vivo Approaches
    Parmar, Hamendra Singh
    Bhinchar, Mahesh Kumar
    Bhatia, Muskan
    Chordia, Nikita
    Raval, Ishan
    Chauhan, Digvijay Singh
    Manivannan, E.
    Jatwa, Rameshwar
    Kumar, Anil
    CURRENT PHARMACEUTICAL DESIGN, 2014, 20 (32) : 5212 - 5217
  • [30] Exploring the Antiproliferative and Antioxidant Effects of Fagonia cretica Thereof: An In Vitro and In Vivo Evaluation
    Kashif, Muhammad
    Abbas, Arshad
    Nasir, Amar
    Rehman, Aziz Ur
    Rehman, Eram
    Jamal, Muhammad Ameen
    Kazi, Mohsin
    MICROSCOPY RESEARCH AND TECHNIQUE, 2025,