Exploring the Antioxidant Potential of Talisia esculenta Using In Vitro and In Vivo Approaches

被引:2
|
作者
Cordeiro, Maria Lucia da Silva [1 ,2 ]
Aquino-Martins, Veronica Giuliani de Queiroz [1 ,2 ]
da Silva, Ariana Pereira [1 ,2 ]
Naliato, Georggia Fatima Silva [2 ,3 ]
Silveira, Elielson Rodrigo [4 ]
Theodoro, Raquel Cordeiro [2 ,3 ]
da Santos, Deborah Yara Alves Cursino [4 ]
Rocha, Hugo Alexandre Oliveira [2 ,5 ]
Scortecci, Katia Castanho [1 ,2 ]
机构
[1] Univ Fed Rio Grande Norte UFRN, Dept Biol Celular & Genet, Lab Transformacao Plantas & Anal Microscopia LTPAM, BR-59078970 Natal, RN, Brazil
[2] Univ Fed Rio Grande Norte UFRN, Ctr Biociencias, Programa Posgrad Bioquim & Biol Mol, BR-59072900 Natal, RN, Brazil
[3] Univ Fed Rio Grande Norte UFRN, Inst Med Trop, BR-59077080 Natal, RN, Brazil
[4] Univ Sao Paulo, Dept Bot, Lab Fitoquim, BR-05508090 Sao Paulo, SP, Brazil
[5] Univ Fed Rio Grande Norte UFRN, Dept Bioquim, Lab Biotecnol Polimeros Nat BIOPOL, BR-59078970 Natal, RN, Brazil
关键词
medicinal plant; phenolic compounds; Sapindaceae; Tenebrio molitor; oxidative damage; CuSO4; stress; OXIDATIVE STRESS; COPPER; IRON; CHELATION; APOPTOSIS; TOXICITY; DAMAGE; MODEL; ASSAY;
D O I
10.3390/nu15173855
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Medicinal plants, such as Talisia esculenta, are rich in antioxidant biomolecules, which are used in the treatment and prevention of many diseases. The antioxidant potential of T. esculenta extracts obtained from leaves and fruit peels was investigated using biochemical and 3T3 cell line assays as well as in vivo assays using an organism model Tenebrio molitor. Four extracts were tested: hydroethanolic extracts from leaves (HF) and from fruit peels (HC), and infusion extracts from leaves (IF) and from fruit peels (IC). The biochemical assays demonstrated an antioxidant capacity verified by TAC, reducing power, DPPH, and copper chelating assays. None of the extracts exhibited cytotoxicity against 3T3 cells, instead offering a protection against CuSO4-induced oxidative stress. The antioxidant activity observed in the extracts, including their role as free radical scavengers, copper chelators, and stress protectors, was further confirmed by T. molitor assays. The CLAE-DAD analysis detected phenolic compounds, including gallic acid, rutin, and quercitrin, as the main constituents of the samples. This study highlights that leaf and fruit peels extracts of T. esculenta could be effective protectors against ROS and copper-induced stress in cellular and invertebrate models, and they should be considered as coadjutants in the treatment and prevention of diseases related to oxidative stress and for the development of natural nutraceutical products.
引用
收藏
页数:20
相关论文
共 50 条
  • [2] Preliminary evaluation of antioxidant, antiproliferative and antimutagenic activities of pitomba (Talisia esculenta)
    Neri-Numa, Iramaia Angelica
    de Carvalho-Silva, Luciano Bruno
    Macedo Ferreira, Jose Emilson
    Tomazela Machado, Ana Rita
    Malta, Luciana Gomes
    Tasca Gois Ruiz, Ana Lucia
    de Carvalho, Joao Ernesto
    Pastore, Glaucia Maria
    LWT-FOOD SCIENCE AND TECHNOLOGY, 2014, 59 (02) : 1233 - 1238
  • [3] Antifungal and marker effects of Talisia esculenta lectin on Microsporum canis in vitro
    Pinheiro, A.Q.
    Melo, D.F.
    MacEdo, L.M.
    Freire, M.G.M.
    Rocha, M.F.G.
    Sidrim, J.J.C.
    Brilhante, R.S.N.
    Teixeira, E.H.
    Campello, C.C.
    Pinheiro, D.C.S.N.
    Lima, M.G.S.
    Journal of Applied Microbiology, 2009, 107 (06): : 2063 - 2069
  • [4] Exploring the zoonotic potential of animal prion diseases In vivo and in vitro approaches
    Barria, Marcelo A.
    Ironside, James W.
    Head, Mark W.
    PRION, 2014, 8 (01) : 85 - 91
  • [5] Antifungal and marker effects of Talisia esculenta lectin on Microsporum canis in vitro
    Pinheiro, A. Q.
    Melo, D. F.
    Macedo, L. M.
    Freire, M. G. M.
    Rocha, M. F. G.
    Sidrim, J. J. C.
    Brilhante, R. S. N.
    Teixeira, E. H.
    Campello, C. C.
    Pinheiro, D. C. S. N.
    Lima, M. G. S.
    JOURNAL OF APPLIED MICROBIOLOGY, 2009, 107 (06) : 2063 - 2069
  • [6] Antioxidant, antidiabetic, and anticholinesterase potential of Chenopodium murale L. extracts using in vitro and in vivo approaches
    Ahmed, Zubaida Rasheed
    Uddin, Zaheer
    Shah, Syed Wadood Ali
    Zahoor, Muhammad
    Alotaibi, Amal
    Shoaib, Mohammad
    Ghias, Mehreen
    Ul Bari, Wasim
    OPEN CHEMISTRY, 2022, 20 (01): : 1171 - 1186
  • [7] Potential effects of lipid lowering and antioxidant activity of exosomes from Phascolosoma esculenta: in vivo and in vitro studies
    Yang, Lin
    Yi, Xue
    Duan, Meitao
    Mahal, Ahmed
    Chen, Binbin
    Zhang, Zhiqiang
    Ren, Jungang
    Chen, Ming
    Meng, Chen
    Xu, Moxun
    Obaidullah, Ahmad J.
    Wang, Chen
    Liu, Mingyuan
    FRONTIERS IN PHARMACOLOGY, 2025, 16
  • [8] In Vitro and In Vivo Regulation of Antioxidant Potential of Fenugreek
    Kamal, Raka
    Yadav, Sunita
    IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL, 2010, 46 : S208 - S209
  • [9] Exploring the anti-inflammatory potential of Colocasia esculenta root extract in in-vitro and in-vivo models of inflammation
    Baro, Momita Rani
    Das, Manas
    Kalita, Anuradha
    Das, Bhabajyoti
    Sarma, Kishore
    JOURNAL OF ETHNOPHARMACOLOGY, 2023, 303
  • [10] Exploring the wound healing potential of Lobostemon fruticosus using in vitro and in vivo bioassays
    Kgosana, Mashilo R.
    Sandasi, Maxleene
    Ncube, Efficient
    Vermaak, Ilze
    Gouws, Chrisna
    Viljoen, Alvaro M.
    JOURNAL OF ETHNOPHARMACOLOGY, 2025, 336