The role of perivascular adipose tissue-secreted adipocytokines in cardiovascular disease

被引：5

作者：

Cai, Meichao ^{[1
]}

Zhao, Dongsheng ^{[1
]}

Han, Xiao ^{[1
]}

Han, Shuang ^{[2
]}

Zhang, Wenxin ^{[1
]}

Zang, Zhennan ^{[1
]}

Gai, Chenchen ^{[1
]}

Rong, Rong ^{[1
]}

Gao, Tian ^{[1
]}

机构：

[1] Shandong Univ Tradit Chinese Med, Sch Pharm, Jinan, Peoples R China

[2] Shanghai Jiao Tong Univ, Sch Med, Int Peace Matern & Child Hlth Hosp, Shanghai, Peoples R China

来源：

FRONTIERS IN IMMUNOLOGY | 2023年 / 14卷

关键词：

perivascular adipose tissue (PVAT); adipocytokines (adipokines); white adipose tissue (WAT); brown adipose tissue (BAT); cardiovascular disease; NITRIC-OXIDE SYNTHASE; INFLAMMATORY RESPONSE; ADIPONECTIN RECEPTORS; MESSENGER-RNA; EXPRESSION; OMENTIN; GROWTH; CELLS; LEPTIN; FAT;

D O I：

10.3389/fimmu.2023.1271051

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Perivascular adipose tissue and the vessel wall are connected through intricate bidirectional paracrine and vascular secretory signaling pathways. The secretion of inflammatory factors and oxidative products by the vessel wall in the diseased segment has the ability to influence the phenotype of perivascular adipocytes. Additionally, the secretion of adipokines by perivascular adipose tissue exacerbates the inflammatory response in the diseased vessel wall. Therefore, quantitative and qualitative studies of perivascular adipose tissue are of great value in the context of vascular inflammation and may provide a reference for the assessment of cardiovascular ischemic disease.

引用

页数：8

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