ATP-responsive Mn(<sc>ii</sc>)-based T1 contrast agent for MRI

被引：0
|
作者：
Anbu, Sellamuthu [1 ,2 ,3 ]
Kenning, Lawerence [4 ]
Stasiuk, Graeme J. [5 ]
机构：
[1] Univ Hull, Dept Chem, Cottingham Rd, Kingston Upon Hull HU6 7RX, England
[2] Univ Hull, Dept Biomed Sci, Cottingham Rd, Kingston Upon Hull HU6 7RX, England
[3] Univ East Anglia, Sch Chem, Norwich Res Pk, Norwich NR4 7TJ, England
[4] Royal Infirm Hosp NHS Trust, MRI Ctr, Anlaby Rd, Kingston Upon Hull HU3 2JZ, England
[5] Kings Coll London, Sch Biomed Engn & Imaging Sci, Dept Imaging Chem & Biol, St Thomas Hosp, Fourth Floor Lambeth Wing, London SE1 7EH, England
来源：
CHEMICAL COMMUNICATIONS | 2023年 / 59卷 / 91期
基金：
英国工程与自然科学研究理事会;
关键词：
RESONANCE-IMAGING CONTRAST; EXTRACELLULAR ATP; OXIDATIVE-PHOSPHORYLATION; INTRACELLULAR ATP; CELLS; METASTASIS; TRANSITION; COMPLEXES; PROBES;
D O I：
10.1039/d3cc03430e
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel diacetylpyridylcarbohydrazide-DAPyCOHz-based manganese(ii) chelate with dipicolylamine/zinc(ii) (DPA/Zn2+) arms (MnLDPA-Zn2) was developed for adenosine triphosphate (ATP) responsive magnetic resonance imaging (MRI) T-1 contrast applications. Compound 2 shows enhanced relaxivity (r(1) = 11.52 mM(-1) s(-1)) upon selective ATP binding over other phosphates.
引用
收藏
页码：13623 / 13626
页数：4
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