ATP-responsive Mn(<sc>ii</sc>)-based T1 contrast agent for MRI

被引：0

作者：

Anbu, Sellamuthu ^{[1
,2
,3
]}

Kenning, Lawerence ^{[4
]}

Stasiuk, Graeme J. ^{[5
]}

机构：

[1] Univ Hull, Dept Chem, Cottingham Rd, Kingston Upon Hull HU6 7RX, England

[2] Univ Hull, Dept Biomed Sci, Cottingham Rd, Kingston Upon Hull HU6 7RX, England

[3] Univ East Anglia, Sch Chem, Norwich Res Pk, Norwich NR4 7TJ, England

[4] Royal Infirm Hosp NHS Trust, MRI Ctr, Anlaby Rd, Kingston Upon Hull HU3 2JZ, England

[5] Kings Coll London, Sch Biomed Engn & Imaging Sci, Dept Imaging Chem & Biol, St Thomas Hosp, Fourth Floor Lambeth Wing, London SE1 7EH, England

来源：

CHEMICAL COMMUNICATIONS | 2023年 / 59卷 / 91期

基金：

英国工程与自然科学研究理事会;

关键词：

RESONANCE-IMAGING CONTRAST; EXTRACELLULAR ATP; OXIDATIVE-PHOSPHORYLATION; INTRACELLULAR ATP; CELLS; METASTASIS; TRANSITION; COMPLEXES; PROBES;

D O I：

10.1039/d3cc03430e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel diacetylpyridylcarbohydrazide-DAPyCOHz-based manganese(ii) chelate with dipicolylamine/zinc(ii) (DPA/Zn2+) arms (MnLDPA-Zn2) was developed for adenosine triphosphate (ATP) responsive magnetic resonance imaging (MRI) T-1 contrast applications. Compound 2 shows enhanced relaxivity (r(1) = 11.52 mM(-1) s(-1)) upon selective ATP binding over other phosphates.

引用

页码：13623 / 13626

页数：4

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