Synthesis and Biological Evaluation of Novel Oxazolidinone Derivatives Containing Dithiocarbamate Moiety as Antibacterial Agents

Background In this article, a series of novel oxazolidinone derivatives containing dithiocarbamate moieties have been designed and synthesized.Materials and Methods Their antibacterial activities were measured against Staphylococcus aureus, vancomycin-resistant Enterococcus faecium (VREF), linezolid-resistant Enterococcus faecalis (LREF) and Streptococcus agalactiae (GBS) by minimal inhibitory concentration (MIC) assays.Results Dithiocarbamates were found conducive to the maintenance of antibacterial activity. Most of them exhibited potent activity against Gram-positive pathogens comparable to linezolid. The most promising compound A8 showed remarkable antibacterial activity against S.aureus, VREF, LREF, and GBS pathogens with MIC values between 0.25 and 1 mu g/mL, which might be a promising drug candidate for further investigation.Conclusion A series of novel oxazolidinone derivatives containing dithiocarbamate moieties might be promising drug candidates for further investigation.