Synthesis and Antibacterial Activities of Novel Phosphonate Derivatives Containing Quinolinone Moiety

被引：6

作者：

Yang, Jiaqiang ^{[1
]}

Hu, Yuewei ^{[1
]}

Gu, Qing ^{[1
]}

Li, Minggang ^{[1
]}

Lin, Mingqiang ^{[2
]}

Song, Baoan ^{[3
]}

机构：

[1] Zunyi Med Coll, Sch Pharm, Zunyi 563003, Peoples R China

[2] Zunyi Med Coll, Lab Microbiol & Immunol, Zunyi 563003, Peoples R China

[3] Guizhou Univ, Ctr Res & Dev Fine Chem, Guiyang 550025, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2014年 / 34卷 / 04期

关键词：

quinolinone; alpha-aminophosphonate; amide; synthesis; antibacterial activity; AMINOPHOSPHONATES; ACIDS;

D O I：

10.6023/cjoc201311027

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

According to substructure link principle, a series of novel phosphonate derivatives bearing quinolinone moiety were designed and synthesized. The structures of the products were confirmed by IR, H-1 NMR and MS data. The antibacterial activities of the products against S. aureus, E. coli, drug-resistant S. aureus were evaluated by the agar dilution method. The results demonstrated that some compound exhibited superior activities against drug-resistant S. aureus compared with norfloxacin. Especially, compound mk showed more potent activities against MRSA15(#) with minimum inhibitory concentration (MIC) values of 6.2 mg/mL, and against QRSA7(#) with MIC values of 3.1 mg/mL.

引用

页码：829 / 834

页数：6

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