Large clones of pre-existing T cells drive early immunity against SARS-COV-2 and LCMV infection

被引：4

作者：

Milighetti, Martina ^{[1
]}

Peng, Yanchu ^{[2
,3
]}

Tan, Cedric ^{[5
]}

Mark, Michal ^{[6
]}

Nageswaran, Gayathri ^{[1
]}

Byrne, Suzanne ^{[1
]}

Ronel, Tahel ^{[1
]}

Peacock, Tom ^{[1
]}

Mayer, Andreas ^{[1
]}

Chandran, Aneesh ^{[1
]}

Rosenheim, Joshua ^{[1
]}

Whelan, Matthew ^{[1
]}

Yao, Xuan ^{[3
]}

Liu, Guihai ^{[3
]}

Felce, Suet Ling ^{[3
]}

Dong, Tao ^{[2
,3
]}

Mentzer, Alexander J. ^{[4
]}

Knight, Julian C. ^{[3
,4
]}

Balloux, Francois ^{[5
]}

Greenstein, Erez ^{[6
]}

Reich-Zeliger, Shlomit ^{[6
]}

Pade, Corinna ^{[7
]}

Gibbons, Joseph M. ^{[7
]}

Semper, Amanda ^{[8
]}

Brooks, Tim ^{[8
]}

Otter, Ashley ^{[8
]}

Altmann, Daniel M. ^{[9
]}

Boyton, Rosemary J. ^{[10
,11
]}

Maini, Mala K. ^{[1
]}

McKnight, Aine ^{[7
]}

Manisty, Charlotte ^{[12
]}

Treibel, Thomas A. ^{[12
]}

Moon, James C. ^{[12
]}

COVIDsortium Investigators, COVIDsortium Investigators

Noursadeghi, Mahdad ^{[1
]}

Chain, Benny ^{[1
]}

机构：

[1] UCL, Div Infect & Immun, London WC1E 6BT, England

[2] Univ Oxford, MRC Weatherall Inst Mol Med, Radcliffe Dept Med, MRC Human Immunol Unit, Oxford, England

[3] Univ Oxford, Oxford Inst COI, Chinese Acad Med Sci CAMS, Oxford, England

[4] Univ Oxford, Wellcome Ctr Human Genet, Oxford, England

[5] UCL, UCL Genet Inst, London WC1E 6BT, England

[6] Weizmann Inst Sci, Dept Syst Immunol, IL-7610001 Rehovot, Israel

[7] Queen Mary Univ London, Blizard Inst, Barts & London Sch Med & Dent, London E1 4NS, England

[8] UK Hlth Secur Agcy, Salisbury SP4 0JG, England

[9] Imperial Coll London, Dept Immunol & Inflammat, London SW7 2BX, England

[10] Imperial Coll London, Dept Infect Dis, London W12 0NN, England

[11] Guys & St Thomas NHS Fdn Trust, Royal Brompton Hosp, Lung Div, London, England

[12] UCL, Inst Cardiovasc Sci, London WC1E 6BT, England

来源：

ISCIENCE | 2023年 / 26卷 / 06期

基金：

“创新英国”项目; 美国国家卫生研究院; 欧盟地平线“2020”; 英国惠康基金; 英国医学研究理事会;

关键词：

LYMPHOCYTIC CHORIOMENINGITIS VIRUS; DYNAMICS; CD4(+); SEQUENCES; RESPONSES; DISEASE;

D O I：

10.1016/j.isci.2023.106937

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

T cell responses precede antibody and may provide early control of infection. We analyzed the clonal basis of this rapid response following SARS-COV-2 infection. We applied T cell receptor (TCR) sequencing to define the trajectories of individ-ual T cell clones immediately. In SARS-COV-2 PCR+ individuals, a wave of TCRs strongly but transiently expand, frequently peaking the same week as the first positive PCR test. These expanding TCR CDR3s were enriched for sequences functionally annotated as SARS-COV-2 specific. Epitopes recognized by the ex-panding TCRs were highly conserved between SARS-COV-2 strains but not with circulating human coronaviruses. Many expanding CDR3s were present at high frequency in pre-pandemic repertoires. Early response TCRs specific for lympho-cytic choriomeningitis virus epitopes were also found at high frequency in the preinfection naive repertoire. High-frequency naive precursors may allow the T cell response to respond rapidly during the crucial early phases of acute viral infection.

引用

页数：21

共 50 条

[31] Identifying molecular insight of synergistic complexities for SARS-CoV-2 infection with pre-existing type 2 diabetes
Islam, M. Babul
Chowdhury, Utpala Nanda
Nain, Zulkar
Uddin, Shahadat
Ahmed, Mohammad Boshir
Moni, Mohammad Ali
COMPUTERS IN BIOLOGY AND MEDICINE, 2021, 136
[32] Pre-existing immunity to SARS-CoV-2 associates with strong T cell responses induced by inactivated COVID-19 vaccines
Yi, Xuan
Wang, Yuhao
Li, Quanrun
Li, Xiaoyi
Zhang, Panli
Fu, Xin
Gu, Shuqin
Zhang, Daqian
Liu, Xiaoyi
Lou, Haonan
Wu, Yuemei
Tang, Libo
Hou, Jinlin
Li, Yongyin
JOURNAL OF MEDICAL VIROLOGY, 2023, 95 (03)
[33] Acquired immunity against SARS-CoV-2 infection and vaccination
Renia, Laurent
Ng, Lisa F. P.
EMBO MOLECULAR MEDICINE, 2023, 15 (12)
[34] Reduced Frequency of SARS-CoV-2 Symptom and RNAemia Development in Pre-Symptomatic Blood Donors with Pre-Existing Immunity
Saa, P.
Fink, R.
Di Germanio, C.
Krysztof, D.
Nester, T.
Kessler, D.
Townsend, R.
Kamel, H.
Stone, M.
Norris, P.
TRANSFUSION, 2023, 63 : 63A - 64A
[35] Immunity to SARS-CoV-2 infection
Pepper, Marion
IMMUNOLOGICAL REVIEWS, 2022, 309 (01) : 5 - 7
[36] Does pre-existing immunity determine the course of SARS-CoV-2 infection in health-care workers? Single-center experience
Laura, Luka
Dalmatin-Dragisic, Monika
Martinovic, Katarina
Tutis, Borka
Herceg, Ivana
Arapovic, Maja
Arapovic, Jurica
INFECTION, 2023, 51 (02) : 323 - 330
[37] Does pre-existing immunity determine the course of SARS-CoV-2 infection in health-care workers? Single-center experience
Luka Laura
Monika Dalmatin-Dragišić
Katarina Martinović
Borka Tutiš
Ivana Herceg
Maja Arapović
Jurica Arapović
Infection, 2023, 51 : 323 - 330
[38] Distinguishing SARS-CoV-2 bonafide re-infection from pre-existing minor variant reactivation
Siqueira, Juliana D.
Goes, Livia R.
Alves, Brunna M.
da Silva, Ana Carla P.
de Carvalho, Pedro S.
Cicala, Claudia
Arthos, James
Viola, Joao P. B.
Soares, Marcelo A.
INFECTION GENETICS AND EVOLUTION, 2021, 90
[39] Outcomes of SARS-CoV-2 infection among children and young people with pre-existing rheumatic and musculoskeletal diseases
Kearsley-Fleet, Lianne
Chang, Min-Lee
Lawson-Tovey, Saskia
Costello, Ruth
Fingerhutova, Sarka
Svestkova, Natalie
Belot, Alexandre
Aeschlimann, Florence A.
Melki, Isabelle
Kone-Paut, Isabelle
Eulert, Sascha
Kallinich, Tilmann
Berkun, Yackov
Uziel, Yosef
Raffeiner, Bernd
Ramos, Filipa Oliveira
Clemente, Daniel
Dackhammar, Christina
Wulffraat, Nico M.
Waite, Helen
Strangfeld, Anja
Mateus, Elsa F.
Machado, Pedro M.
Natter, Marc
Hyrich, Kimme L.
ANNALS OF THE RHEUMATIC DISEASES, 2022, 81 (07) : 998 - 1005
[40] Long-Term Outcomes of Patients with Pre-Existing Essential Tremor After SARS-CoV-2 Infection
Pakan, Rachel
Hadidchi, Roham
Al-Ani, Yousef
Piskun, Hannah
Duong, Katie S.
Henry, Sonya
Wang, Stephen
Maurer, Carine W.
Duong, Tim Q.
DIAGNOSTICS, 2024, 14 (24)

← 1 2 3 4 5 →