Phenolic constituents with antibacterial from Eleutherine bulbosa

被引：1

作者：

Sun, Zhaocui ^{[1
]}

Li, Qinglong ^{[1
]}

Zhang, Jiawen ^{[1
]}

Sun, Zhonghao ^{[1
]}

Wu, Haifeng ^{[1
]}

Liang, Hanqiao ^{[2
]}

Ma, Min ^{[3
]}

Huang, Linfang ^{[1
]}

Xu, Xudong ^{[1
]}

Ma, Guoxu ^{[1
]}

机构：

[1] Peking Union Med Coll & Chinese Acad Med Sci, Inst Med Plant Dev, Key Lab Bioact Subst & Resources Utilizat Chinese, Minist Educ, Beijing 100193, Peoples R China

[2] Beijing City Univ, Dept Biomed, Beijing 100094, Peoples R China

[3] Qinghai Minzu Univ, Key Lab Resource Chem & Ecoenvironm Protect Qingha, Xining 810007, Peoples R China

来源：

FITOTERAPIA | 2024年 / 172卷

关键词：

Eleutherine bulbosa; Phenolic constituents; Dimers; Antibacterial activity; DERIVATIVES; AMERICANA; NAPHTHALENE;

D O I：

10.1016/j.fitote.2023.105787

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Eleutherine bulbosa (Mill.) Urb. is a medicinal and edible plant with various benefits for humans and animals. In this work, four new phenolic constituents (1-4), along with six known phenolic compounds (5-10) were obtained from the red bulbs of E. bulbosa. Their structures with absolute configurations were characterized by extensive spectroscopic analysis, combined with HR-ESI-MS and quantum mechanical electronic circular dichroism (ECD). Compounds 1 and 2 are novel homologous and heterodimers, respectively, featuring an unusual spiro ring system. All isolated phenolic constituents were tested for their antibacterial effects. The results revealed four phenolic compounds 1-3 and 7 showed moderate antibacterial activity against Bacillus subtilis, Staphylococcus aureus and Escherichia coli with minimum inhibitory concentration (MIC) values ranging from 15.6 to 250.0 mu g/mL.

引用

页数：7

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