Phenolic constituents with antibacterial from Eleutherine bulbosa

被引：1
|
作者：
Sun, Zhaocui [1 ]
Li, Qinglong [1 ]
Zhang, Jiawen [1 ]
Sun, Zhonghao [1 ]
Wu, Haifeng [1 ]
Liang, Hanqiao [2 ]
Ma, Min [3 ]
Huang, Linfang [1 ]
Xu, Xudong [1 ]
Ma, Guoxu [1 ]
机构：
[1] Peking Union Med Coll & Chinese Acad Med Sci, Inst Med Plant Dev, Key Lab Bioact Subst & Resources Utilizat Chinese, Minist Educ, Beijing 100193, Peoples R China
[2] Beijing City Univ, Dept Biomed, Beijing 100094, Peoples R China
[3] Qinghai Minzu Univ, Key Lab Resource Chem & Ecoenvironm Protect Qingha, Xining 810007, Peoples R China
来源：
FITOTERAPIA | 2024年 / 172卷
关键词：
Eleutherine bulbosa; Phenolic constituents; Dimers; Antibacterial activity; DERIVATIVES; AMERICANA; NAPHTHALENE;
D O I：
10.1016/j.fitote.2023.105787
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Eleutherine bulbosa (Mill.) Urb. is a medicinal and edible plant with various benefits for humans and animals. In this work, four new phenolic constituents (1-4), along with six known phenolic compounds (5-10) were obtained from the red bulbs of E. bulbosa. Their structures with absolute configurations were characterized by extensive spectroscopic analysis, combined with HR-ESI-MS and quantum mechanical electronic circular dichroism (ECD). Compounds 1 and 2 are novel homologous and heterodimers, respectively, featuring an unusual spiro ring system. All isolated phenolic constituents were tested for their antibacterial effects. The results revealed four phenolic compounds 1-3 and 7 showed moderate antibacterial activity against Bacillus subtilis, Staphylococcus aureus and Escherichia coli with minimum inhibitory concentration (MIC) values ranging from 15.6 to 250.0 mu g/mL.
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页数：7
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