From Basic Research to Clinical Practice: Considerations for Treatment Drugs for Silicosis

被引:16
|
作者
Li, Rou [1 ]
Kang, Huimin [1 ]
Chen, Shi [1 ]
机构
[1] Hunan Normal Univ, Key Lab Mol Epidemiol Hunan Prov, Changsha 410013, Peoples R China
基金
中国国家自然科学基金;
关键词
silicosis; IPF; pulmonary fibrosis; treatment drugs; INDUCED PULMONARY-FIBROSIS; INDUCED LUNG FIBROSIS; ALVEOLAR MACROPHAGES; CATENIN PATHWAY; TGF-BETA/SMAD; TOTAL EXTRACT; BLEOMYCIN; ACTIVATION; INHIBITION; DIAGNOSIS;
D O I
10.3390/ijms24098333
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Silicosis, characterized by irreversible pulmonary fibrosis, remains a major global public health problem. Nowadays, cumulative studies are focusing on elucidating the pathogenesis of silicosis in order to identify preventive or therapeutic antifibrotic agents. However, the existing research on the mechanism of silica-dust-induced pulmonary fibrosis is only the tip of the iceberg and lags far behind clinical needs. Idiopathic pulmonary fibrosis (IPF), as a pulmonary fibrosis disease, also has the same problem. In this study, we examined the relationship between silicosis and IPF from the perspective of their pathogenesis and fibrotic characteristics, further discussing current drug research and limitations of clinical application in silicosis. Overall, this review provided novel insights for clinical treatment of silicosis with the hope of bridging the gap between research and practice in silicosis.
引用
收藏
页数:23
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