From Basic Research to Clinical Practice: Considerations for Treatment Drugs for Silicosis

被引:16
|
作者
Li, Rou [1 ]
Kang, Huimin [1 ]
Chen, Shi [1 ]
机构
[1] Hunan Normal Univ, Key Lab Mol Epidemiol Hunan Prov, Changsha 410013, Peoples R China
基金
中国国家自然科学基金;
关键词
silicosis; IPF; pulmonary fibrosis; treatment drugs; INDUCED PULMONARY-FIBROSIS; INDUCED LUNG FIBROSIS; ALVEOLAR MACROPHAGES; CATENIN PATHWAY; TGF-BETA/SMAD; TOTAL EXTRACT; BLEOMYCIN; ACTIVATION; INHIBITION; DIAGNOSIS;
D O I
10.3390/ijms24098333
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Silicosis, characterized by irreversible pulmonary fibrosis, remains a major global public health problem. Nowadays, cumulative studies are focusing on elucidating the pathogenesis of silicosis in order to identify preventive or therapeutic antifibrotic agents. However, the existing research on the mechanism of silica-dust-induced pulmonary fibrosis is only the tip of the iceberg and lags far behind clinical needs. Idiopathic pulmonary fibrosis (IPF), as a pulmonary fibrosis disease, also has the same problem. In this study, we examined the relationship between silicosis and IPF from the perspective of their pathogenesis and fibrotic characteristics, further discussing current drug research and limitations of clinical application in silicosis. Overall, this review provided novel insights for clinical treatment of silicosis with the hope of bridging the gap between research and practice in silicosis.
引用
收藏
页数:23
相关论文
共 50 条
  • [21] Glutamatergic transmission in schizophrenia: from basic research to clinical practice
    Kantrowitz, Joshua
    Javitt, Daniel C.
    CURRENT OPINION IN PSYCHIATRY, 2012, 25 (02) : 96 - 102
  • [22] Skin senescence-from basic research to clinical practice
    Dorf, Natalia
    Maciejczyk, Mateusz
    FRONTIERS IN MEDICINE, 2024, 11
  • [23] Allergic drug reactions: from basic research to clinical practice
    Blanca, Miguel
    Thong, Bernard Y. -H.
    CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, 2011, 11 (04) : 275 - 278
  • [24] OPIOID ANTAGONISTS - FROM BASIC RESEARCH TO CLINICAL-PRACTICE
    OBRIEN, CP
    INTERNATIONAL JOURNAL OF NEUROSCIENCE, 1986, 31 (1-4) : 279 - 279
  • [25] Predictive genetic testing: From basic research to clinical practice
    Holtzman, NA
    Murphy, PD
    Watson, MS
    Barr, PA
    SCIENCE, 1997, 278 (5338) : 602 - 605
  • [26] Translating basic research into clinical practice
    Schulz, J.
    JOURNAL OF NEUROCHEMISTRY, 2017, 142 : 77 - 77
  • [27] Computer-aided oncology: From basic research to clinical practice
    Sgouros, J
    EUROPEAN JOURNAL OF CANCER, 1999, 35 : S136 - S136
  • [28] Exosomal LncRNAs and hepatocellular Carcinoma: From basic research to clinical practice
    Li, Liangyun
    Bi, Yihui
    Diao, Shaoxi
    Li, Xiaofeng
    Yuan, Tong
    Xu, Tao
    Huang, Cheng
    Li, Jun
    BIOCHEMICAL PHARMACOLOGY, 2022, 200
  • [29] Targeted Therapy in Hematological Malignancies: From Basic Research to Clinical Practice
    Ma, Haiqing
    Mallampati, Saradhi
    An, Gang
    Wang, Jin
    BIOMED RESEARCH INTERNATIONAL, 2015, 2015
  • [30] Editorial: Update on glaucoma research: from basic science to clinical practice
    Martucci, Alessio
    Pinazo-Duran, Maria Dolores
    Nucci, Carlo
    FRONTIERS IN MEDICINE, 2025, 12