Oncogenic role for an EWS-FLI1 suppressor

被引：0
|
作者：
Apfelbaum, April A. [1 ]
Lawlor, Elizabeth R. [1 ]
机构：
[1] Seattle Childrens Res Inst, Seattle, WA 98101 USA
来源：
NATURE CELL BIOLOGY | 2023年 / 25卷 / 02期
关键词：
D O I：
10.1038/s41556-022-01067-8
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Tight regulation of the activity of EWS-ETS fusion proteins is essential for the growth of Ewing sarcomas. Two new studies show that the transcriptional repressor ETV6 is essential for tumour growth, acting to restrain fusion-protein-mediated gene activation, and revealing the importance of tissue-specific transcription factors to oncogenesis.
引用
收藏
页码：214 / 216
页数：3
相关论文
共 50 条
  • [31] The type2 EWS-Fli1 protein causes a greater up-regulation of elements of the human stromelysin 3 promoter compared with EWS-Fli1 Type 1 and Fli1.
    Ubhi, B. S.
    JOURNAL OF CLINICAL ONCOLOGY, 2006, 24 (18) : 529S - 529S
  • [32] Transcriptional modules involving EWS-FLI1 and SRF in Ewing sarcoma
    Katschnig, Anna M.
    Kauer, Maximilian O.
    Aryee, Dave N. T.
    Schwentner, Raphaela
    Lawlor, Elizabeth
    Kovar, Heinrich
    CANCER RESEARCH, 2016, 76
  • [33] Targeting EWS-FLI1 with mithramycin analogues for Ewing sarcoma treatment
    Leggas, Markos
    Niloy, Kumar K.
    Yetijaram, Rajesh
    Horn, Jamie
    Kazuto, Yasuda
    Prisinzano, Thomas
    Thorson, Jon S.
    Tsoikov, Oleg
    Rohr, Jurgen
    MOLECULAR CANCER THERAPEUTICS, 2023, 22 (12)
  • [34] Destabilization of EWS-Fli1 protein by deubiquitinase inhibition in Ewing Sarcoma
    Wang, Shan
    Kittler, Ralf
    CANCER RESEARCH, 2017, 77
  • [35] TARGETING EWS-FLI1 DRIVING GENE: PRELIMINARY DATA OF PHASE 1 PBI-ShRNA EWS/FLI1 LIPOPLEX
    Ghisoli, Maurizio
    Maning, Luisa
    Nemunaitis, John
    Rao, Donald
    Wallraven, Gladice
    Jay, Chris
    PEDIATRIC BLOOD & CANCER, 2018, 65
  • [36] EWS-FLI1 as a molecular target: Identification of inhibitors for a disordered protein
    Barber-Rotenberg, Julie S.
    Kong, Yali
    Schnure, Nilan
    Dakshanamurthy, Sivanesan
    Frazier, Peter
    Erkizan, Hayriye V.
    Brown, Milton L.
    Uren, Aykut
    Toretsky, Jeffrey A.
    MOLECULAR CANCER THERAPEUTICS, 2009, 8 (12)
  • [37] GLI1 Is a Direct Transcriptional Target of EWS-FLI1 Oncoprotein
    Beauchamp, Elspeth
    Bulut, Gulay
    Abaan, Ogan
    Chen, Kevin
    Merchant, Akil
    Matsui, William
    Endo, Yoshimi
    Rubin, Jeffrey S.
    Toretsky, Jeffrey
    Ueren, Aykut
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 284 (14) : 9074 - 9082
  • [38] Gene expression response to EWS-FLI1 in mouse embryonic cartilage
    Tanaka, Miwa
    Aisaki, Ken-Ichi
    Kitajima, Satoshi
    Igarashi, Katsuhide
    Kanno, Jun
    Nakamura, Takuro
    GENOMICS DATA, 2014, 2 : 296 - 298
  • [39] Ewing sarcoma network model through EWS-FLI1 signaling
    Stoll, G.
    Surdez, D.
    Tirode, F.
    Laud-Duval, K.
    Guillon, N.
    Boeva, V.
    Delattre, O.
    Barillot, E.
    Zinovyev, A.
    EJC SUPPLEMENTS, 2010, 8 (05): : 209 - 209
  • [40] An EWS-FLI1/MRTF gene regulatory network in Ewing sarcoma
    Katschnig, Anna M.
    Kauer, Maximilian
    Schwentner, Raphaela
    Aryee, Dave N. T.
    Lawlor, Elizabeth
    Kovar, Heinrich
    CANCER RESEARCH, 2015, 75
12345