Oncogenic role for an EWS-FLI1 suppressor

被引：0
|
作者：
Apfelbaum, April A. [1 ]
Lawlor, Elizabeth R. [1 ]
机构：
[1] Seattle Childrens Res Inst, Seattle, WA 98101 USA
来源：
NATURE CELL BIOLOGY | 2023年 / 25卷 / 02期
关键词：
D O I：
10.1038/s41556-022-01067-8
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Tight regulation of the activity of EWS-ETS fusion proteins is essential for the growth of Ewing sarcomas. Two new studies show that the transcriptional repressor ETV6 is essential for tumour growth, acting to restrain fusion-protein-mediated gene activation, and revealing the importance of tissue-specific transcription factors to oncogenesis.
引用
收藏
页码：214 / 216
页数：3
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