In vivo imaging of the neuronal response to spinal cord injury: a narrative review

被引：0
|
作者：
Deng, Junhao [1 ,2 ,3 ]
Sun, Chang [1 ,2 ,4 ]
Zheng, Ying [5 ]
Gao, Jianpeng [1 ,2 ]
Cui, Xiang [1 ,2 ]
Wang, Yu [6 ,7 ]
Zhang, Licheng [1 ,2 ]
Tang, Peifu [1 ,2 ]
机构：
[1] Chinese Peoples Liberat Army Gen Hosp, Med Ctr 4, Dept Orthoped, Beijing, Peoples R China
[2] Natl Clin Res Ctr Orthoped Sports Med & Rehabil, Beijing, Peoples R China
[3] Tsinghua Univ, Sch Life Sci, Beijing, Peoples R China
[4] Air Force Med Ctr, PLA, Dept Orthoped, Beijing, Peoples R China
[5] Med Sch Chinese PLA, Beijing, Peoples R China
[6] Chinese Peoples Liberat Army Gen Hosp, Med Ctr 1, Inst Orthoped, Beijing, Peoples R China
[7] Key Lab Musculoskeletal Trauma & War Injuries PLA, Key Lab Regenerat Med Orthoped, Beijing, Peoples R China
来源：
NEURAL REGENERATION RESEARCH | 2024年 / 19卷 / 04期
关键词：
anterior horn neurons; calcium imaging; central nervous system; dorsal horn neurons; dorsal root ganglion; in vivo imaging; neuronal response; spinal cord injury; spinal cord; two-photon microscopy; MINIATURE 2-PHOTON MICROSCOPY; NEUROPATHIC PAIN; NETWORKS; REVEALS; REGENERATION; DEEP; TRANSPLANTATION; INTERNEURONS; FERROPTOSIS; MOTONEURON;
D O I：
10.4103/1673-5374.382225
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Deciphering the neuronal response to injury in the spinal cord is essential for exploring treatment strategies for spinal cord injury (SCI). However, this subject has been neglected in part because appropriate tools are lacking. Emerging in vivo imaging and labeling methods offer great potential for observing dynamic neural processes in the central nervous system in conditions of health and disease. This review first discusses in vivo imaging of the mouse spinal cord with a focus on the latest imaging techniques, and then analyzes the dynamic biological response of spinal cord sensory and motor neurons to SCI. We then summarize and compare the techniques behind these studies and clarify the advantages of in vivo imaging compared with traditional neuroscience examinations. Finally, we identify the challenges and possible solutions for spinal cord neuron imaging.
引用
收藏
页码：811 / 817
页数：7
相关论文
共 50 条
  • [41] Diagnosis and Management of Cardiovascular Risk in Individuals With Spinal Cord Injury: A Narrative Review
    Lagu, Tara
    Schroth, Samantha L.
    Haywood, Carol
    Heinemann, Allen
    Kessler, Allison
    Morse, Leslie
    Khan, Sadiya S.
    Kershaw, Kiarri N.
    Nash, Mark S.
    CIRCULATION, 2023, 148 (03) : 268 - 277
  • [42] Neuronal dysfunction in chronic spinal cord injury
    Hubli, M.
    Bolliger, M.
    Dietz, V.
    SPINAL CORD, 2011, 49 (05) : 582 - 587
  • [43] Factors influencing patients' hope in stroke and spinal cord injury: A narrative review
    Soundy, Andrew
    Stubbs, Brendon
    Freeman, Paul
    Coffee, Pete
    Roskell, Carolyn
    INTERNATIONAL JOURNAL OF THERAPY AND REHABILITATION, 2014, 21 (05): : 210 - 218
  • [44] Neuronal replacement strategies for spinal cord injury
    Whittemore, SR
    JOURNAL OF NEUROTRAUMA, 1999, 16 (08) : 667 - 673
  • [45] Neuronal reprogramming in treating spinal cord injury
    Chen, Xuanyu
    Li, Hedong
    NEURAL REGENERATION RESEARCH, 2022, 17 (07) : 1440 - 1445
  • [46] Neuronal repair and replacement in spinal cord injury
    Bareyre, Florence M.
    JOURNAL OF THE NEUROLOGICAL SCIENCES, 2008, 265 (1-2) : 63 - 72
  • [47] Neuronal dysfunction in chronic spinal cord injury
    M Hubli
    M Bolliger
    V Dietz
    Spinal Cord, 2011, 49 : 582 - 587
  • [48] Letter to the editor "In vivo imaging in experimental spinal cord injury - Techniques and trends"
    Murugan, Ramadurai
    BRAIN AND SPINE, 2024, 4
  • [49] In vivo imaging of spinal cord in contusion injury model mice by multiphoton microscopy
    Oshima, Y.
    Horiuchi, H.
    Ogata, T.
    Hikita, A.
    Miura, H.
    Imamura, T.
    IMAGING, MANIPULATION, AND ANALYSIS OF BIOMOLECULES, CELLS, AND TISSUES XII, 2014, 8947
  • [50] In vivo imaging of blood-spinal cord barrier permeability with dynamic contrast enhanced MRI of spinal cord injury
    Bilgen, M
    Dogan, B
    Narayana, PA
    2002 IEEE INTERNATIONAL SYMPOSIUM ON BIOMEDICAL IMAGING, PROCEEDINGS, 2002, : 153 - 156
12345