In vivo imaging of the neuronal response to spinal cord injury: a narrative review

被引：0

作者：

Deng, Junhao ^{[1
,2
,3
]}

Sun, Chang ^{[1
,2
,4
]}

Zheng, Ying ^{[5
]}

Gao, Jianpeng ^{[1
,2
]}

Cui, Xiang ^{[1
,2
]}

Wang, Yu ^{[6
,7
]}

Zhang, Licheng ^{[1
,2
]}

Tang, Peifu ^{[1
,2
]}

机构：

[1] Chinese Peoples Liberat Army Gen Hosp, Med Ctr 4, Dept Orthoped, Beijing, Peoples R China

[2] Natl Clin Res Ctr Orthoped Sports Med & Rehabil, Beijing, Peoples R China

[3] Tsinghua Univ, Sch Life Sci, Beijing, Peoples R China

[4] Air Force Med Ctr, PLA, Dept Orthoped, Beijing, Peoples R China

[5] Med Sch Chinese PLA, Beijing, Peoples R China

[6] Chinese Peoples Liberat Army Gen Hosp, Med Ctr 1, Inst Orthoped, Beijing, Peoples R China

[7] Key Lab Musculoskeletal Trauma & War Injuries PLA, Key Lab Regenerat Med Orthoped, Beijing, Peoples R China

来源：

NEURAL REGENERATION RESEARCH | 2024年 / 19卷 / 04期

关键词：

anterior horn neurons; calcium imaging; central nervous system; dorsal horn neurons; dorsal root ganglion; in vivo imaging; neuronal response; spinal cord injury; spinal cord; two-photon microscopy; MINIATURE 2-PHOTON MICROSCOPY; NEUROPATHIC PAIN; NETWORKS; REVEALS; REGENERATION; DEEP; TRANSPLANTATION; INTERNEURONS; FERROPTOSIS; MOTONEURON;

D O I：

10.4103/1673-5374.382225

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Deciphering the neuronal response to injury in the spinal cord is essential for exploring treatment strategies for spinal cord injury (SCI). However, this subject has been neglected in part because appropriate tools are lacking. Emerging in vivo imaging and labeling methods offer great potential for observing dynamic neural processes in the central nervous system in conditions of health and disease. This review first discusses in vivo imaging of the mouse spinal cord with a focus on the latest imaging techniques, and then analyzes the dynamic biological response of spinal cord sensory and motor neurons to SCI. We then summarize and compare the techniques behind these studies and clarify the advantages of in vivo imaging compared with traditional neuroscience examinations. Finally, we identify the challenges and possible solutions for spinal cord neuron imaging.

引用

页码：811 / 817

页数：7

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