Relative biological effectiveness for epithermal neutron beam contaminated with fast neutrons in the linear accelerator-based boron neutron capture therapy system coupled to a solid-state lithium target

被引：6

作者：

Nakamura, Satoshi ^{[1
,2
,3
]}

Imamichi, Shoji ^{[2
,4
,5
]}

Shimada, Kenzi ^{[6
]}

Takemori, Mihiro ^{[1
,2
,7
]}

Kanai, Yui ^{[2
,4
,8
]}

Iijima, Kotaro ^{[1
]}

Chiba, Takahito ^{[1
,7
]}

Nakayama, Hiroki ^{[1
,7
]}

Nakaichi, Tetsu ^{[1
,2
]}

Mikasa, Shohei ^{[1
]}

Urago, Yuka ^{[1
,7
]}

Kashihara, Tairo ^{[9
]}

Takahashi, Kana ^{[9
]}

Nishio, Teiji ^{[3
]}

Okamoto, Hiroyuki ^{[1
]}

Itami, Jun ^{[9
]}

Ishiai, Masamichi ^{[4
]}

Suzuki, Minoru ^{[10
]}

Igaki, Hiroshi ^{[2
,9
,11
]}

Masutani, Mitsuko ^{[2
,4
,5
]}

机构：

[1] Natl Canc Ctr, Div Radiat Safety & Qual Assurance, 5 1 1 Tsukiji, Chuo ku, Tokyo 1040045, Japan

[2] Natl Canc Ctr, Exploratory Oncol Res & Clin Trial Ctr, Div Boron Neutron Capture Therapy, 5 1 1 Tsukiji, Chuo ku, Tokyo 1040045, Japan

[3] Osaka Univ, Grad Sch Med, Div Hlth Sci, Med Phys Lab, 1 7 Yamadaoka, Suita, Osaka 5650871, Japan

[4] Natl Canc Ctr, Cent Radioisotope Div, 5 1 1 Tsukiji, Chuo ku, Tokyo 1040045, Japan

[5] Nagasaki Univ, Dept Mol & Genom Biomed, Grad Sch Biomed Sci, 1 7 1 Sakamoto, Nagasaki 8528588, Japan

[6] Canc Intelligence Care Syst Inc, 3 5 7 Ariake,Koto ku, Tokyo 1350063, Japan

[7] Grad Sch Human Hlth Sci, Dept Radiol Sci, 7 2 10 Higashiogu,Arakawa ku, Tokyo 1168551, Japan

[8] Tokyo Inst Technol, Inst Innovat Res, Lab Zero Carbon Energy, 2 12 1 Ookayama,Meguro ku, Tokyo 1525880, Japan

[9] Natl Canc Ctr, Dept Radiat Oncol, 5 1 1 Tsukiji, Chuo ku, Tokyo 1040045, Japan

[10] Kyoto Univ, Inst Integrated Radiat & Nucl Sci, 2 Asashiro Nishi, Kumatori cho, Osaka 5900494, Japan

[11] Tsukiji 5 1 1, Chuo ku, Tokyo 1040045, Japan

来源：

JOURNAL OF RADIATION RESEARCH | 2023年 / 64卷 / 04期

基金：

日本学术振兴会;

关键词：

neutron beam; solid-state Li target; relative biological effectiveness (RBE); accelerator-based BNCT system; boron neutron capture therapy (BNCT); RECURRENT HEAD; NECK-CANCER; B-10; BNCT; GLIOBLASTOMA; IRRADIATION; FACILITY; BRAIN;

D O I：

10.1093/jrr/rrad037

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

This study aimed to quantify the relative biological effectiveness (RBE) for epithermal neutron beam contaminated with fast neutrons in the accelerator-based boron neutron capture therapy (BNCT) system coupled to a solid-state lithium target. The experiments were performed in National Cancer Center Hospital (NCCH), Tokyo, Japan. Neutron irradiation with the system provided by Cancer Intelligence Care Systems (CICS), Inc. was performed. X-ray irradiation, which was assigned as the reference group, was also performed using a medical linear accelerator (LINAC) equipped in NCCH. The four cell lines (SAS, SCCVII, U87-MG and NB1RGB) were utilized to quantify RBE value for the neutron beam. Before both of those irradiations, all cells were collected and dispensed into vials. The doses of 10% cell surviving fraction (SF) (D10) were calculated by LQ model fitting. All cell experiments were conducted in triplicate at least. Because the system provides not only neutrons, but gamma-rays, the contribution from the gamma-rays to the survival fraction were subtracted in this study. D10 value of SAS, SCCVII, U87-MG and NB1RGB for the neutron beam was 4.26, 4.08, 5.81 and 2.72 Gy, respectively, while that acquired by the X-ray irradiation was 6.34, 7.21, 7.12 and 5.49 Gy, respectively. Comparison of both of the D10 values, RBE value of SAS, SCCVII, U87-MG and NB1RGB for the neutron beam was calculated as 1.7, 2.2, 1.3 and 2.5, respectively, and the average RBE value was 1.9. This study investigated RBE of the epithermal neutron beam contaminated with fast neutrons in the accelerator-based BNCT system coupled to a solid-state lithium target.

引用

页码：661 / 667

页数：7

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