Clearance of dead cells by efferocytosis promotes liver metastasis in pancreatic cancer

被引：0

作者：

Astuti, Yuliana ^{[1
]}

Schmid, Michael C. ^{[1
]}

机构：

[1] Univ Liverpool, Liverpool, England

来源：

NATURE CANCER | 2024年 / 5卷 / 05期

关键词：

D O I：

10.1038/s43018-024-00732-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pancreatic cancer liver metastases show high levels of immunosuppressive macrophages, which promote tumor growth. We found that blocking the efferocytosis pathway during early-stage metastasis in a mouse model inhibited the development of immunosuppressive activity in monocyte-derived macrophages, which restored T cell activation and reduced the metastatic tumor burden.

引用

页码：699 / 700

页数：2

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