Clearance of dead cells by efferocytosis promotes liver metastasis in pancreatic cancer

被引：0
|
作者：
Astuti, Yuliana [1 ]
Schmid, Michael C. [1 ]
机构：
[1] Univ Liverpool, Liverpool, England
来源：
NATURE CANCER | 2024年 / 5卷 / 05期
关键词：
D O I：
10.1038/s43018-024-00732-1
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Pancreatic cancer liver metastases show high levels of immunosuppressive macrophages, which promote tumor growth. We found that blocking the efferocytosis pathway during early-stage metastasis in a mouse model inhibited the development of immunosuppressive activity in monocyte-derived macrophages, which restored T cell activation and reduced the metastatic tumor burden.
引用
收藏
页码：699 / 700
页数：2
相关论文
共 50 条
  • [31] Sonic hedgehog promotes metastasis and desmoplasia in pancreatic cancer
    Bailey, Jennifer M.
    Hollingsworth, Michael A.
    CANCER BIOMARKERS, 2008, 4 (03) : 131 - 131
  • [32] Engrailed-1 promotes pancreatic cancer metastasis
    Xu, Jihao
    Roe, Jae-Seok
    Lee, EunJung
    Tonelli, Claudia
    Somervile, Tim
    Yao, Melissa
    Milazzo, Joseph
    Tiriac, Herve
    Kolarzyk, Anna
    Lee, Esak
    Grem, Jeam
    Lazenby, Audrey
    Grunkemeyer, James
    Hollingsworth, Michael
    Grandgenett, Paul
    Borowsky, Alexander
    Park, Youngkyu
    Vakoc, Christopher
    Tuveson, David
    Hwang, Chang-Il
    CANCER RESEARCH, 2024, 84 (02)
  • [33] LRH1 promotes pancreatic cancer metastasis
    Lin, Qiushi
    Aihara, Arihiro
    Chung, Waihong
    Li, Yu
    Chen, Xuesong
    Huang, Zheping
    Weng, Shaofan
    Carlson, Rolf I.
    Nadolny, Christina
    Wands, Jack R.
    Dong, Xiaoqun
    CANCER LETTERS, 2014, 350 (1-2) : 15 - 24
  • [34] Engrailed-1 Promotes Pancreatic Cancer Metastasis
    Xu, Jihao
    Roe, Jae-Seok
    Lee, Eunjung
    Tonelli, Claudia
    Ji, Keely Y.
    Younis, Omar W.
    Somervile, Tim D. D.
    Yao, Melissa
    Milazzo, Joseph P.
    Tiriac, Herve
    Kolarzyk, Anna M.
    Lee, Esak
    Grem, Jean L.
    Lazenby, Audrey J.
    Grunkemeyer, James A.
    Hollingsworth, Michael A.
    Grandgenett, Paul M.
    Borowsky, Alexander D.
    Park, Youngkyu
    Vakoc, Christopher R.
    Tuveson, David A.
    Hwang, Chang-Il
    ADVANCED SCIENCE, 2024, 11 (06)
  • [35] Expression of snail in pancreatic cancer promotes metastasis and chemoresistance
    Yin, Tao
    Wang, Chunyou
    Liu, Tao
    Zhao, Gang
    Zha, Yunhong
    Yang, Ming
    JOURNAL OF SURGICAL RESEARCH, 2007, 141 (02) : 196 - 203
  • [36] Hepatocytes compensate for the loss of PHGDH in pancreatic cancer cells during liver metastasis
    Ganguly, Koelina
    Yamamoto, Keisuke
    Rosado, Joel Encarnacion
    Sohn, Albert
    Biancur, Douglas
    Lin, Elaine
    White, Elshadai
    Kimmelman, Alec C.
    CANCER RESEARCH, 2024, 84 (06)
  • [37] CD110 is Associated With Pancreatic Cancer Patient Survival and Promotes Cancer Progression, Especially Liver Metastasis
    Yan, Z.
    Ohuchida, K.
    Zheng, B.
    Okumura, T.
    Koikawa, K.
    Takesue, S.
    Nakayama, N.
    Shirahane, K.
    Shimizu, Y.
    Moriyama, T.
    Ohtsuka, T.
    Mizumoto, K.
    Oda, Y.
    Nakamura, M.
    PANCREAS, 2017, 46 (10) : 1444 - 1444
  • [38] Pancreatic cancer exosomes prime the liver for metastasis
    Katrina Ray
    Nature Reviews Gastroenterology & Hepatology, 2015, 12 (7) : 371 - 371
  • [39] Pancreatic Cancer With Metastasis to Liver: Report of a Case
    Qureshi, Zaheer A.
    Reyes, Sherry
    Biswas, Sharmi
    Bodepudi, Sri Lekha
    Thomas, Stacey E.
    Altaf, Faryal
    AMERICAN JOURNAL OF GASTROENTEROLOGY, 2018, 113 : S1607 - S1608
  • [40] Role of Pancreatic Stellate Cells in Pancreatic Cancer Metastasis
    Xu, Zhihong
    Vonlaufen, Alain
    Phillips, Phoebe A.
    Fiala-Beer, Eva
    Zhang, Xuguo
    Yang, Lu
    Biankin, Andrew V.
    Goldstein, David
    Pirola, Romano C.
    Wilson, Jeremy S.
    Apte, Minoti V.
    AMERICAN JOURNAL OF PATHOLOGY, 2010, 177 (05): : 2585 - 2596
12345