Clearance of dead cells by efferocytosis promotes liver metastasis in pancreatic cancer

被引：0
|
作者：
Astuti, Yuliana [1 ]
Schmid, Michael C. [1 ]
机构：
[1] Univ Liverpool, Liverpool, England
来源：
NATURE CANCER | 2024年 / 5卷 / 05期
关键词：
D O I：
10.1038/s43018-024-00732-1
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Pancreatic cancer liver metastases show high levels of immunosuppressive macrophages, which promote tumor growth. We found that blocking the efferocytosis pathway during early-stage metastasis in a mouse model inhibited the development of immunosuppressive activity in monocyte-derived macrophages, which restored T cell activation and reduced the metastatic tumor burden.
引用
收藏
页码：699 / 700
页数：2
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