A nonadride derivative from the marine-derived fungus Aspergillus chevalieri PSU-AMF79

被引：7

作者：

Ningsih, Baiq Nila Sari ^{[1
,2
]}

Rukachaisirikul, Vatcharin ^{[1
,2
]}

Phongpaichit, Souwalak ^{[3
]}

Preedanon, Sita ^{[4
]}

Sakayaroj, Jariya ^{[5
]}

Muanprasat, Chatchai ^{[6
]}

机构：

[1] Prince Songkla Univ, Fac Sci, Div Phys Sci, Hat Yai, Songkhla, Thailand

[2] Prince Songkla Univ, Fac Sci, Ctr Excellence Innovat Chem, Hat Yai, Songkhla, Thailand

[3] Prince Songkla Univ, Fac Sci, Div Biol Sci, Hat Yai, Songkhla, Thailand

[4] Natl Sci & Technol Dev Agcy NSTDA, Natl Biobank Thailand NBT, Pathum Thani, Thailand

[5] Walailak Univ, Sch Sci, Nakhonsithammarat, Thailand

[6] Mahidol Univ, Ramathibodi Hosp, Chakri Naruebodindra Med Inst, Fac Med, Samut Prakarn, Thailand

来源：

NATURAL PRODUCT RESEARCH | 2023年 / 37卷 / 14期

关键词：

Aspergillus chevalieri; marine-derived fungus; nonadride; dioxopiperazine; enantiomer; antimicrobial activity; TMEM16A inhibitory activity; SECTION ASPERGILLUS; METABOLITE; ANHYDRIDE;

D O I：

10.1080/14786419.2022.2039651

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

One new nonadride enantiomer, ent-epiheveadride, along with five known dioxopiperazine derivatives were isolated from the marine-derived fungus Aspergillus chevalieri PSU-AMF79. Their structures were identified by extensive spectroscopic analysis. The absolute configuration of ent-epiheveadride was determined by comparison of the specific rotation and electronic circular dichroism data with those of related known compounds. It exhibited antifungal activity against Cryptococcus neoformans ATCC90113 flucytosine-resistant and Candida albicans NCPF3153 with the MIC values of 128 and 200 mu g/mL, respectively. In addition, the known L-alanyl-L-tryptophan anhydride displayed TMEM16A inhibitory activity with 65.0% inhibition at a concentration of 5 mu g/mL.

引用

页码：2311 / 2318

页数：8

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