A nonadride derivative from the marine-derived fungus Aspergillus chevalieri PSU-AMF79

被引：7
|
作者：
Ningsih, Baiq Nila Sari [1 ,2 ]
Rukachaisirikul, Vatcharin [1 ,2 ]
Phongpaichit, Souwalak [3 ]
Preedanon, Sita [4 ]
Sakayaroj, Jariya [5 ]
Muanprasat, Chatchai [6 ]
机构：
[1] Prince Songkla Univ, Fac Sci, Div Phys Sci, Hat Yai, Songkhla, Thailand
[2] Prince Songkla Univ, Fac Sci, Ctr Excellence Innovat Chem, Hat Yai, Songkhla, Thailand
[3] Prince Songkla Univ, Fac Sci, Div Biol Sci, Hat Yai, Songkhla, Thailand
[4] Natl Sci & Technol Dev Agcy NSTDA, Natl Biobank Thailand NBT, Pathum Thani, Thailand
[5] Walailak Univ, Sch Sci, Nakhonsithammarat, Thailand
[6] Mahidol Univ, Ramathibodi Hosp, Chakri Naruebodindra Med Inst, Fac Med, Samut Prakarn, Thailand
来源：
NATURAL PRODUCT RESEARCH | 2023年 / 37卷 / 14期
关键词：
Aspergillus chevalieri; marine-derived fungus; nonadride; dioxopiperazine; enantiomer; antimicrobial activity; TMEM16A inhibitory activity; SECTION ASPERGILLUS; METABOLITE; ANHYDRIDE;
D O I：
10.1080/14786419.2022.2039651
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
One new nonadride enantiomer, ent-epiheveadride, along with five known dioxopiperazine derivatives were isolated from the marine-derived fungus Aspergillus chevalieri PSU-AMF79. Their structures were identified by extensive spectroscopic analysis. The absolute configuration of ent-epiheveadride was determined by comparison of the specific rotation and electronic circular dichroism data with those of related known compounds. It exhibited antifungal activity against Cryptococcus neoformans ATCC90113 flucytosine-resistant and Candida albicans NCPF3153 with the MIC values of 128 and 200 mu g/mL, respectively. In addition, the known L-alanyl-L-tryptophan anhydride displayed TMEM16A inhibitory activity with 65.0% inhibition at a concentration of 5 mu g/mL.
引用
收藏
页码：2311 / 2318
页数：8
相关论文
共 50 条
  • [21] Lumazine Peptides from the Marine-Derived Fungus Aspergillus terreus
    You, Minjung
    Liao, Lijuan
    Hong, Soo Hyun
    Park, Wanki
    Kwon, Dah In
    Lee, Jeeyeon
    Noh, Minsoo
    Oh, Dong-Chan
    Oh, Ki-Bong
    Shin, Jongheon
    MARINE DRUGS, 2015, 13 (03): : 1290 - 1303
  • [22] Alkaloidal Metabolites from a Marine-Derived Aspergillus sp Fungus
    Liao, Lijuan
    You, Minjung
    Chung, Beom Koo
    Oh, Dong-Chan
    Oh, Ki-Bong
    Shin, Jongheon
    JOURNAL OF NATURAL PRODUCTS, 2015, 78 (03): : 349 - 354
  • [23] Discovery of a new biphenyl derivative by epigenetic manipulation of marine-derived fungus Aspergillus versicolor
    Zhu, Jing Xuan
    Ding, Lijian
    He, Shan
    NATURAL PRODUCT RESEARCH, 2019, 33 (08) : 1191 - 1195
  • [24] Dehydroxychlorofusarielin B, an antibacterial polyoxygenated decalin derivative from the marine-derived fungus Aspergillus sp.
    Nguyen, Hung Phi
    Zhang, Dahai
    Lee, Uk
    Kang, Jung Sook
    Choi, Hong Dae
    Son, Byeng Wha
    JOURNAL OF NATURAL PRODUCTS, 2007, 70 (07): : 1188 - 1190
  • [25] Caryophyllene sesquiterpenes, chromones and 10-membered macrolides from the marine-derived fungus Pseudopestalotiopsis sp. PSU-AMF45
    Putra, Haryadi N.
    Rukachaisirikul, Vatcharin
    Saithong, Saowanit
    Phongpaichit, Souwalak
    Preedanon, Sita
    Sakayaroj, Jariya
    Hadsadee, Sarinya
    Jungsuttiwong, Siriporn
    TETRAHEDRON, 2019, 75 (38)
  • [26] Prenylated Indole Diketopiperazines from the Marine-Derived Fungus Aspergillus versicolor
    Peng, Jixing
    Gao, Huquan
    Li, Jing
    Ai, Jing
    Geng, Meiyu
    Zhang, Guojian
    Zhu, Tianjiao
    Gu, Qianqun
    Li, Dehai
    JOURNAL OF ORGANIC CHEMISTRY, 2014, 79 (17): : 7895 - 7904
  • [27] Aspergillusol A, an α-Glucosidase Inhibitor from the Marine-Derived Fungus Aspergillus aculeatus
    Ingavat, Nattha
    Dobereiner, Jeffrey
    Wiyakrutta, Suthep
    Mahidol, Chulabhorn
    Ruchirawat, Somsak
    Kittakoop, Prasat
    JOURNAL OF NATURAL PRODUCTS, 2009, 72 (11): : 2049 - 2052
  • [28] Secondary metabolites from a marine-derived fungus Aspergillus carneus Blochwitz
    Zhuravleva, Olesya I.
    Afiyatullov, Shamil Sh
    Denisenko, Vladimir A.
    Ermakova, Svetlana P.
    Slinkina, Natalya N.
    Dmitrenok, Pavel S.
    Kim, Natalya Yu
    PHYTOCHEMISTRY, 2012, 80 : 123 - 131
  • [29] Antimicrobial aflatoxins from the marine-derived fungus Aspergillus flavus 092008
    Wang, Hui
    Lu, Zhenyu
    Qu, Hai-Jun
    Liu, Peipei
    Miao, Chengdu
    Zhu, Tonghan
    Li, Jing
    Hong, Kui
    Zhu, Weiming
    ARCHIVES OF PHARMACAL RESEARCH, 2012, 35 (08) : 1387 - 1392
  • [30] Naphto-Γ-pyrones from the marine-derived fungus Aspergillus foetidus
    Antonov, Alexander S.
    Leshchenko, Elena V.
    Zhuravleva, Olesya I.
    Dyshlovoy, Sergey A.
    von Amsberg, Gunhild
    Popov, Roman S.
    Denisenko, Vladimir A.
    Kirichuk, Natalya N.
    Afiyatullov, Shamil Sh.
    NATURAL PRODUCT RESEARCH, 2021, 35 (01) : 131 - 134
12345