An MYC-Driven Vicious Circuit Is a Targetable Achilles' Heel in Lymphoma

被引：1

作者：

Wilson, Erica B. ^{[1
]}

Klein, Ulf ^{[1
,2
]}

机构：

[1] Univ Leeds, Leeds Inst Med Res St Jamess, Leeds, England

[2] Univ Leeds, Leeds Inst Med Res St Jamess, Leeds LS9 7TF, England

来源：

BLOOD CANCER DISCOVERY | 2023年 / 4卷 / 04期

关键词：

D O I：

10.1158/2643-3230.BCD-23-0053

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In this issue of Blood Cancer Discovery, Nakanishi et al. uncover a critical role for the elevated activity of the translation initiation factor eIF5A in the malignant growth of MYC-driven lymphoma. eIF5A is posttrans-lationally modifi ed by hypusination through MYC oncoprotein-mediated hyperactivation of the polyamine- hypusine circuit, which may represent a promising therapeutic target because an enzyme of this circuit that is required for hypusinating eIF5A proved to be essential for lymphoma development.

引用

页码：248 / 251

页数：4

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