An MYC-Driven Vicious Circuit Is a Targetable Achilles' Heel in Lymphoma

被引：1
|
作者：
Wilson, Erica B. [1 ]
Klein, Ulf [1 ,2 ]
机构：
[1] Univ Leeds, Leeds Inst Med Res St Jamess, Leeds, England
[2] Univ Leeds, Leeds Inst Med Res St Jamess, Leeds LS9 7TF, England
来源：
BLOOD CANCER DISCOVERY | 2023年 / 4卷 / 04期
关键词：
D O I：
10.1158/2643-3230.BCD-23-0053
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
In this issue of Blood Cancer Discovery, Nakanishi et al. uncover a critical role for the elevated activity of the translation initiation factor eIF5A in the malignant growth of MYC-driven lymphoma. eIF5A is posttrans-lationally modifi ed by hypusination through MYC oncoprotein-mediated hyperactivation of the polyamine- hypusine circuit, which may represent a promising therapeutic target because an enzyme of this circuit that is required for hypusinating eIF5A proved to be essential for lymphoma development.
引用
收藏
页码：248 / 251
页数：4
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